Trial reportHuman vaccines & immunotherapeutics2014
Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial.
Trial report in Human vaccines & immunotherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01057771 (Meditation and Exercise for Prevention of Acute Respiratory Infection), which is not on this map. Cited by 24 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meditation and Exercise for Prevention of Acute Respiratory Infection
Who cites it
24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials.PLoS medicine · 2021Pooled it
- Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.Psychotherapy and psychosomatics · 2019Pooled it
- Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review.BMC complementary and alternative medicine · 2017Pooled it
- Exercise prior to influenza vaccination for limiting influenza incidence and its related complications in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.Annals of the New York Academy of Sciences · 2016Pooled it
- Mindfulness versus Physical Exercise: Effects of Two Recovery Strategies on Mental Health, Stress and Immunoglobulin A during Lunch Breaks. A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trial.PloS one · 2018Trial
- Association of interleukin-8 and neutrophils with nasal symptom severity during acute respiratory infection.Journal of medical virology · 2015Trial
- Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy.npj aging · 2025Review
- Measuring Vaccine Responses in the Multiplex Era.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Physical activity and sleep relate to antibody maintenance following naturalistic infection and/or vaccination in older adults.Brain, behavior, & immunity - health · 2023Article
- Individual participant data systematic review and meta-analysis of randomised controlled trials assessing adult mindfulness-based programmes for mental health promotion in non-clinical settings.Nature. Mental health · 2023Article
- Why should I vaccinate? The role of mindfulness and health-protective behaviours during the COVID-19 pandemic.Health policy and technology · 2023Article
- Impact of Diet and Lifestyle on Vaccine Efficacy in Adults Aged 55 and Older: A Review.Integrative medicine (Encinitas, Calif.) · 2022Review
- Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis.Vaccines · 2022Review
- Yoga, Meditation, Breathing Exercises, and Inflammatory Biomarkers with Possible Implications in COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Insights Into Sibling Relationships and Longevity From Genetics of Healthy Ageing Nonagenarians: The Importance of Optimisation, Resilience and Social Networks.Frontiers in psychology · 2022Article
- To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2.Neurobiology of stress · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStrategies to improve influenza vaccine protection among elderly individuals are an important research priority. Mindfulness-based stress reduction (MBSR) and exercise have been shown to affect aspects of immune function in some populations. We hypothesized that influenza vaccine responses may be enhanced with meditation or exercise training as compared with controls.
resultsNo differences in vaccine responses were found comparing control to MBSR or exercise. Individuals achieving seroprotective levels of influenza antibody ≥160 units had higher optimism, less anxiety, and lower perceived stress than the nonresponders. Age correlated with influenza antibody responses, but not with IFNγ or IL-10 production.
conclusionThe MBSR and exercise training evaluated in this study failed to enhance immune responses to influenza vaccine. However, optimism, perceived stress, and anxiety were correlated in the expected directions with antibody responses to influenza vaccine.
methodsHealthy individuals≥50 y were randomly assigned to exercise (n=47) or MBSR (n=51) training or a waitlist control condition (n=51). Each participant received trivalent inactivated influenza vaccine after 6 weeks, and had blood draws prior to and 3 and 12 weeks after immunization. Serum influenza antibody, nasal immunoglobulin A, and peripheral blood mononuclear cell interferon-γ (IFNγ) and interleukin-10 (IL-10) concentrations were measured. Measures of optimism, perceived stress, and anxiety were obtained over the course of the study. Seroprotection was defined as an influenza antibody concentration≥160 units. Vaccine responses were compared using ANOVA, t tests, and Kruskal-Wallis tests. The correlation between vaccine responses and age was examined with the Pearson test.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.