ArticleNature chemical biology2013
Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation.
Article in Nature chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children.The Journal of allergy and clinical immunology · 2021Trial
- Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation.Drug delivery and translational research · 2024Article
- Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model.Science translational medicine · 2023Article
- Exploring the potential and safety of quantum dots in allergy diagnostics.Microsystems & nanoengineering · 2023Review
- Determination of immunogenic epitopes in major house dust mite allergen, Der p 2, via nanoallergens.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Nanoarchitectures for efficient IgE cross-linking on effector cells to study amoxicillin allergy.Allergy · 2021Article
- Article
- IgE Epitope Profiling for Allergy Diagnosis and Therapy - Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform.Frontiers in immunology · 2020Article
- Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Human monoclonal antibodies to Ara h 2 inhibit allergen-induced, IgE-mediated cell activation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins.Nutrients · 2017Review
- Article
- Determination of Crucial Immunogenic Epitopes in Major Peanut Allergy Protein, Ara h2, via Novel Nanoallergen Platform.Scientific reports · 2017Article
- Antibody purification via affinity membrane chromatography method utilizing nucleotide binding site targeting with a small molecule.The Analyst · 2016Article
- Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Recent advances in engineering polyvalent biological interactions.Biomacromolecules · 2015Review
- Two-allergen model reveals complex relationship between IgE crosslinking and degranulation.Chemistry & biology · 2014Article
- The production and regulation of IgE by the immune system.Nature reviews. Immunology · 2014Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Development of specific inhibitors of allergy has had limited success, in part, owing to a lack of experimental models that reflect the complexity of allergen-IgE interactions. We designed a heterotetravalent allergen (HtTA) system, which reflects epitope heterogeneity, polyclonal response and number of immunodominant epitopes observed in natural allergens, thereby providing a physiologically relevant experimental model to study mast cell degranulation. The HtTA design revealed the importance of weak-affinity epitopes in allergy, particularly when presented with high-affinity epitopes. The effect of selective inhibition of weak-affinity epitope-IgE interactions was investigated with heterobivalent inhibitors (HBIs) designed to simultaneously target the antigen- and nucleotide-binding sites on the IgE Fab. HBI demonstrated enhanced avidity for the target IgE and was a potent inhibitor of degranulation in vitro and in vivo. These results demonstrate that partial inhibition of allergen-IgE interactions was sufficient to prevent mast cell degranulation, thus establishing the therapeutic potential of the HBI design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.