ArticleAmerican journal of obstetrics and gynecology2014
High risk human papillomavirus at entry to prenatal care and risk of preeclampsia.
Article in American journal of obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review.Human vaccines & immunotherapeutics · 2025Pooled it
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis.The Journal of infectious diseases · 2020Pooled it
- Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: a Scandinavian prospective mother-child cohort study.BMC pregnancy and childbirth · 2024Trial
- Article
- The Effect of Human Papillomavirus Infection on Pregnancy Outcomes: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- A new approach for detecting HPV DNA in cervical swabs: comparison of nucleic acid extraction with direct PCR.Virology journal · 2025Article
- Noncoding RNAs improve the predictive power of network medicine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes-A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Maternal HPV Infection: Effects on Pregnancy Outcome.Viruses · 2021Review
- Evidence for HPV DNA in the placenta of women who resorted to elective abortion.BMC pregnancy and childbirth · 2021Article
- Human PapillomavirusPathogens (Basel, Switzerland) · 2020Article
- Exploration of the effect of human papillomavirus (HPV) vaccination in a cohort of pregnant women in Montreal, 2010-2016.Heliyon · 2019Article
- Human Papillomavirus (HPV) Infection in Early Pregnancy: Prevalence and Implications.Infectious diseases in obstetrics and gynecology · 2019Article
- The association between adverse pregnancy outcomes and maternal human papillomavirus infection: a systematic review protocol.Systematic reviews · 2017Article
- Untangling the most probable role for vitamin DDermato-endocrinology · 2017Article
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin.Facts, views & vision in ObGyn · 2016Review
- Metabolic Syndrome and Risk of Cervical Human Papillomavirus Incident and Persistent Infection.Medicine · 2016Observational
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the association between high-risk human papillomavirus (HR-HPV) and preeclampsia.
methodsRetrospective cohort study of women with HR-HPV at entry to prenatal care compared with those with at least 2 normal pap smears. Preeclampsia was defined by clinical guidelines. Unadjusted and adjusted analyses were performed.
resultsThree hundred fourteen women with HR-HPV matched with 628 women with normal pap smears. Exposed HR-HPV patients were younger, had lower body mass index, systolic and diastolic blood pressure at entry to care, and more likely to be nulliparous and smokers. Exposed HR-HPV patients were more likely to develop preeclampsia (10.19% vs 4.94%; P = .004; adjusted odds ratio, 2.18; 95% confidence interval, 1.31-3.65). Women with HR-HPV were also more likely to deliver prematurely at less than 37 and less than 35 weeks.
conclusionHR-HPV is associated with an almost 2-fold increased risk of developing preeclampsia. This warrants a larger study, particularly when HPV infection can be prevented with vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.