Evidence map›Paper›PMID 24096138›Full record

Trial reportNeuroscience2014

An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children.

C E Krafft, J E Pierce, N F Schwarz, L Chi, A L Weinberger, D J Schaeffer, A L Rodrigue, J Camchong, J D Allison, N E Yanasak and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02227095 (Exercise & Overweight Children's Cognition), which is not on this map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02227095 nacompletednot on this map

Exercise & Overweight Children's Cognition

TypeinterventionalSponsorAugusta UniversityRan2008 to 2014Enrolled175ConditionsOverweight and ObesityArmsExercise, After-school program
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  15. Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  16. Article
  17. Sports participation & childhood neurocognitive development.Developmental cognitive neuroscience · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

C E KrafftPsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: krafft@uga.edu.
J E PiercePsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: jepierce@uga.edu.
N F SchwarzPsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: schwarz@uga.edu.
L ChiPsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: lingxi@uga.edu.
A L WeinbergerPsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: abbywein@uga.edu.
D J SchaefferNeuroscience Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: djschaef@uga.edu.
A L RodriguePsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: alr4655@uga.edu.
J CamchongPsychiatry Department, University of Minnesota, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: jcamchong@nbresearch.com.
J D AllisonRadiology Department, Medical College of Georgia, Georgia Regents University, 1102 15th Street, Augusta, GA 30912, USA. Electronic address: jallison@gru.edu.
N E YanasakRadiology Department, Medical College of Georgia, Georgia Regents University, 1102 15th Street, Augusta, GA 30912, USA. Electronic address: nyanasak@gru.edu.
T LiuComputer Science Department, 415 Boyd Graduate Studies Research Center, University of Georgia, Athens, GA 30602, USA. Electronic address: tliu@cs.uga.edu.
C L DavisPediatrics, Georgia Prevention Center, Medical College of Georgia, Institute of Public & Preventive Health, Georgia Regents University, HS-1640, Augusta, GA 30912, USA. Electronic address: cadavis@gru.edu.
J E McDowellPsychology Department, Psychology Building, University of Georgia, Athens, GA 30602, USA; Neuroscience Department, Psychology Building, University of Georgia, Athens, GA 30602, USA. Electronic address: jemcd@uga.edu.
University of Georgia · USAugusta University · USUniversity of Minnesota · US

Funding

Exercise & Overweight Children's CognitionR01HL087923 · NHLBI · AUGUSTA UNIVERSITY · PI DAVIS, CATHERINE LUCY, MCDOWELL, JENNIFER E · 2008 to 2012
$5.2M
NHLBI NIH HHS HL087923-03S2NHLBI NIH HHS R01 HL087923
6 · The paper itself

Abstract

Children with low aerobic fitness have altered brain function compared to higher-fit children. This study examined the effect of an 8-month exercise intervention on resting state synchrony. Twenty-two sedentary, overweight (body mass index ≥85th percentile) children 8-11 years old were randomly assigned to one of two after-school programs: aerobic exercise (n=13) or sedentary attention control (n=9). Before and after the 8-month programs, all subjects participated in resting state functional magnetic resonance imaging scans. Independent components analysis identified several networks, with four chosen for between-group analysis: salience, default mode, cognitive control, and motor networks. The default mode, cognitive control, and motor networks showed more spatial refinement over time in the exercise group compared to controls. The motor network showed increased synchrony in the exercise group with the right medial frontal gyrus compared to controls. Exercise behavior may enhance brain development in children.

Indexed as

RestAnalysis of VarianceAttentionBrainChildCognitionExerciseExercise TherapyFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuropsychological TestsOverweightOxygenaerobic exerciseAFNIAnalysis of Functional Neuroimagesanalysis of varianceANOVAblood oxygenation level-dependentBOLDCASCCCognitive Assessment Systemcognitive controldefault modedefault mode networkdevelopmentDMNecho timefield of viewfMRIFMRIB Software LibrariesFOVFSLfunctional magnetic resonance imagingICAIndependent Component AnalysisMNIMontreal Neurological Instituteobesityrepetition timeresting state fMRIresting state networksrsfMRIRSNsTETR

Identifiers

PMID24096138
PMCPMC3995346
OpenAlexW2072546670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.