ArticleMathematical biosciences2013
A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells.
Article in Mathematical biosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Modeling and high-throughput experimental data uncover the mechanisms underlyingThe Journal of biological chemistry · 2017Article
- Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.PloS one · 2017Article
- Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.American journal of human genetics · 2016Article
- Fertility and fragrance: another cause of Kallmann syndrome.The Journal of clinical investigation · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cells in the pituitary that synthesize luteinizing and follicle-stimulating hormones regulate the relative production of these two key reproductive hormones in response to signals from the hypothalamus. These signals are encoded in the frequency of gonadotrophin-releasing-hormone pulses. In vitro experiments with a murine-derived cell line have identified key elements of the processes that decode the signal to regulate transcription of the subunits encoding these hormones. The mathematical model described in this paper is based on the results of those experiments and advances quantitative understanding of the biochemical decoder. The model consists of non-linear differential equations for each of six processes that lead to the synthesis of follicle-stimulating hormone. Simulations of the model exhibit key characteristics found in the experiments, including a preference for follicle-stimulating hormone synthesis at low pulse frequencies and a loss of this characteristic when a mutation is introduced.
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