Evidence map›Paper›PMID 24095866›Full record

ArticleMicrobes and infection2014

FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus.

Amber D Miller, Sarah E Blutt, Margaret E Conner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbes and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. LAPJournal of virology · 2019
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amber D MillerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Sarah E BluttDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Margaret E ConnerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. Electronic address: mconner@bcm.edu.
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
SUBUNIT ROTAVIRUS VACCINES &MUCOSAL IMMUNITYR01AI024998 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CONNER, MARGARET E. · 1987 to 2013
$4.0M
RESEARCH TRAINING PROGRAM IN MOLECULAR VIROLOGYT32AI007471 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RAMIG, ROBERT FRANKLIN · 1996 to 2010
$2.6M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
SUBUNIT ROTAVIRUS VACCINES AND MUCOSAL IMMUNITYR21AI024998 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CONNER, MARGARET E. · 1999 to 1999
–
NCI NIH HHS CA125123NCI NIH HHS P30 CA125123NCRR NIH HHS RR024574NCRR NIH HHS S10 RR024574NIAID NIH HHS AI036211NIAID NIH HHS AI07471NIAID NIH HHS AI24998NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI024998NIAID NIH HHS R21 AI024998NIAID NIH HHS T32 AI007471NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Regulatory T cells produce TGF-β that contributes to IgA induction by intestinal commensal bacteria but their importance in IgA responses to pathogens has not been determined. Immunity against the enteropathogen, rotavirus, is dependent on intestinal IgA, but whether FoxP3(+) regulatory T cells contribute to this IgA is unknown. Infection with rotavirus increased the numbers of intestinal FoxP3(+) regulatory T cells. Depletion of FoxP3(+) regulatory T cells altered leukocyte activation but did not significantly alter rotavirus clearance or specific antibody levels. These data suggest FoxP3(+) regulatory T cells are not critical for the early antibody response to rotavirus infection.

Indexed as

AnimalsAntibodies, ViralFemaleForkhead Transcription FactorsLeukocytesLymphocyte CountLymphocyte DepletionMaleMiceRotavirusRotavirus InfectionsT-Lymphocytes, RegulatoryAntibodies, ViralForkhead Transcription FactorsFoxp3 protein, mouseFoxP3IgARegulatory T cellsRotavirus

Identifiers

PMID24095866
PMCPMC3947018
OpenAlexW1986513562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.