ArticleMolecular cell2013
Metabolic activation of CaMKII by coenzyme A.
Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism.bioRxiv : the preprint server for biology · 2026Article
- CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability.Molecular neurobiology · 2026Review
- Article
- Aurora Kinase A Regulation by Cysteine Oxidative Modification.Antioxidants (Basel, Switzerland) · 2023Review
- CaMKII binds both substrates and activators at the active site.Cell reports · 2022Article
- The metabolism of cancer cells during metastasis.Nature reviews. Cancer · 2021Review
- Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions.Cell communication and signaling : CCS · 2020Review
- All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation.European journal of pharmacology · 2019Article
- Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II.Cancer research · 2018Article
- Differing molecular response of young and advanced maternal age human oocytes to IVM.Human reproduction (Oxford, England) · 2017Article
- Caspase-2: an orphan enzyme out of the shadows.Oncogene · 2017Review
- Biochemical alterations in the oocyte in support of early embryonic development.Cellular and molecular life sciences : CMLS · 2017Review
- Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis.Frontiers in molecular neuroscience · 2017Article
- Metabolic Regulation of Apoptosis in Cancer.International review of cell and molecular biology · 2016Review
- Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.Digestive diseases and sciences · 2016Article
- Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.Nature chemical biology · 2015Article
- Article
- Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).The Journal of biological chemistry · 2014Article
- Cell biology. Metabolic control of cell death.Science (New York, N.Y.) · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
Abstract
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating CaMKII. We found that CoA directly binds to the CaMKII regulatory domain in the absence of Ca(2+) to activate CaMKII in a calmodulin-dependent manner. Furthermore, we show that CoA inhibits apoptosis not only in X. laevis oocytes but also in Murine oocytes. These findings uncover a direct mechanism of CaMKII regulation by metabolism and further highlight the importance of metabolism in preserving oocyte viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.