ArticleMolecular cell2013
Unusual noncanonical intron editing is important for tRNA splicing in Trypanosoma brucei.
Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Queuosine is incorporated into precursor tRNA before splicing.Nature communications · 2025Article
- Genomic Organization of Trypanosoma cruzi tRNA Genes.Genome biology and evolution · 2025Article
- Variation of tRNA modifications with and without intron dependency.Frontiers in genetics · 2024Review
- tRNARNA (New York, N.Y.) · 2023Article
- The life and times of a tRNA.RNA (New York, N.Y.) · 2023Review
- Making Sense of "Nonsense" and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications.International journal of molecular sciences · 2022Review
- Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications.The FEBS journal · 2021Review
- Modifications of the human tRNA anticodon loop and their associations with genetic diseases.Cellular and molecular life sciences : CMLS · 2021Review
- Nuclear tRNA export in trypanosomes: a journey full of twists and turns guided by tRNA modifications.Parasitology · 2021Review
- From canonical to modified nucleotides: balancing translation and metabolism.Critical reviews in biochemistry and molecular biology · 2020Review
- Genome-wide profiling of RNA editing sites in sheep.Journal of animal science and biotechnology · 2019Article
- The role of RNA modifications in the regulation of tRNA cleavage.FEBS letters · 2018Review
- Retrograde nuclear transport from the cytoplasm is required for tRNARNA biology · 2018Article
- The role of intracellular compartmentalization on tRNA processing and modification.RNA biology · 2018Review
- Genome recoding by tRNA modifications.Open biology · 2016Review
- RNA-DNA sequence differences in Saccharomyces cerevisiae.Genome research · 2016Article
- Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates.PLoS biology · 2016Article
- The essential function of the Trypanosoma brucei Trl1 homolog in procyclic cells is maturation of the intron-containing tRNATyr.RNA (New York, N.Y.) · 2016Article
- The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.Nucleic acids research · 2015Article
- A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing.Molecular and biochemical parasitology · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In cells, tRNAs are synthesized as precursor molecules bearing extra sequences at their 5' and 3' ends. Some tRNAs also contain introns, which, in archaea and eukaryotes, are cleaved by an evolutionarily conserved endonuclease complex that generates fully functional mature tRNAs. In addition, tRNAs undergo numerous posttranscriptional nucleotide chemical modifications. In Trypanosoma brucei, the single intron-containing tRNA (tRNA(Tyr)GUA) is responsible for decoding all tyrosine codons; therefore, intron removal is essential for viability. Using molecular and biochemical approaches, we show the presence of several noncanonical editing events, within the intron of pre-tRNA(Tyr)GUA, involving guanosine-to-adenosine transitions (G to A) and an adenosine-to-uridine transversion (A to U). The RNA editing described here is required for proper processing of the intron, establishing the functional significance of noncanonical editing with implications for tRNA processing in the deeply divergent kinetoplastid lineage and eukaryotes in general.
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