Trial reportJournal of pediatric surgery2013
Developmental outcomes of children with congenital diaphragmatic hernia: a multicenter prospective study.
Trial report in Journal of pediatric surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00950118 (Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessing the Impact of Neighborhood and Built Environment on Pediatric Perioperative Care: A Systematic Review of the Literature.Journal of pediatric surgery · 2024Pooled it
- Brain development in newborns and infants after ECMO.World journal of pediatrics : WJP · 2024Pooled it
- Clinical and environmental risk factors for childhood developmental disabilities: A narrative review (1990-2025).World journal of clinical pediatrics · 2026Review
- What comes next? Follow through care after genetic diagnosis in infancy.Pediatric research · 2026Article
- Isolated congenital diaphragmatic hernia and three-year neurodevelopmental outcomes.Pediatric research · 2025Article
- Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).Pulmonary circulation · 2025Article
- Risk factors for and developmental relation of delayed oral nutrition in infants with congenital diaphragmatic hernia.Pediatric surgery international · 2023Article
- A biopsychosocial model of NICU family adjustment and child development.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Neuropsychological outcome in survivors of congenital diaphragmatic hernia at 5 years of age, what does it tell?European journal of pediatrics · 2023Article
- School age educational outcomes of infants born with congenital diaphragmatic hernia.Birth defects research · 2023Article
- ECMO utilization in infants with congenital diaphragmatic hernia in the USA.World journal of pediatric surgery · 2022Article
- Clinical and genomic characterization of 8p cytogenomic disorders.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene.American journal of human genetics · 2021Article
- Fetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Article
- Seizures Are Associated With Brain Injury in Infants Undergoing Extracorporeal Membrane Oxygenation.Journal of child neurology · 2021Article
- Epidemiology and One-Year Follow-Up of Neonates with CDH-Data from Health Insurance Claims in Germany.Children (Basel, Switzerland) · 2021Article
- Developmental Support for Infants With Genetic Disorders.Pediatrics · 2020Review
- Long-term feeding issue and its impact on the daily life of congenital diaphragmatic hernia survivors: results of the first patient-led survey.Pediatric surgery international · 2020Article
- Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study.BMJ paediatrics open · 2020Article
- Impact of maternal education on the outcome of newborns requiring surgery for congenital malformations.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
purposeTo determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age.
methodsThis is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age.
resultsBSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors.
conclusionCDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
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