ArticleCurrent biology : CB2013
Nuclear repulsion enables division autonomy in a single cytoplasm.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- Competitive resource allocation drives asynchronous and rapid nuclear multiplication in the malaria parasite.Nature communications · 2026Article
- A phase oscillator model of cell cycles reveals nuclear density control in a branched fungal network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- RNA-specific local translation is patterned by condensates for multinucleate cell growth.Nature cell biology · 2026Article
- How condensates tune syncytial translation.Nature cell biology · 2026Article
- Mechanisms of nuclear segregation in a multinucleate multibudding yeast.The Journal of cell biology · 2025Article
- qPCR-based quantification reveals high plant host-specificity of endophytic colonization levels in leaves.American journal of botany · 2025Article
- Genome ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures.Current biology : CB · 2024Article
- Mitigating transcription noise via protein sharing in syncytial cells.Biophysical journal · 2024Article
- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Article
- The nuclear transport factor CSE1 drives macronuclear volume increase and macronuclear node coalescence iniScience · 2023Article
- Plasmodium schizogony, a chronology of the parasite's cell cycle in the blood stage.PLoS pathogens · 2023Review
- Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket.Nature communications · 2022Article
- Pseudocleavage furrows restrict plasma membrane-associated PH domain in syncytial Drosophila embryos.Biophysical journal · 2022Article
- Asynchronous nuclear cycles in multinucleatedScience advances · 2022Article
- Circadian rhythm shows potential for mRNA efficiency and self-organized division of labor in multinucleate cells.PLoS computational biology · 2021Article
- Article
- Syncytia in Fungi.Cells · 2020Review
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCurrent models of cell-cycle control, based on classic studies of fused cells, predict that nuclei in a shared cytoplasm respond to the same CDK activities to undergo synchronous cycling. However, synchrony is rarely observed in naturally occurring syncytia, such as the multinucleate fungus Ashbya gossypii. In this system, nuclei divide asynchronously, raising the question of how nuclear timing differences are maintained despite sharing a common milieu.
resultsWe observe that neighboring nuclei are highly variable in division-cycle duration and that neighbors repel one another to space apart and demarcate their own cytoplasmic territories. The size of these territories increases as a nucleus approaches mitosis and can influence cycling rates. This nonrandom nuclear spacing is regulated by microtubules and is required for nuclear asynchrony, as nuclei that transiently come in very close proximity will partially synchronize. Sister nuclei born of the same mitosis are generally not persistent neighbors over their lifetimes yet remarkably retain similar division cycle times. This indicates that nuclei carry a memory of their birth state that influences their division timing and supports that nuclei subdivide a common cytosol into functionally distinct yet mobile compartments.
conclusionsThese findings support that nuclei use cytoplasmic microtubules to establish "cells within cells." Individual compartments appear to push against one another to compete for cytoplasmic territory and insulate the division cycle. This provides a mechanism by which syncytial nuclei can spatially organize cell-cycle signaling and suggests size control can act in a system without physical boundaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.