Trial reportBiological psychiatry2014
Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study.
Trial report in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
169 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review with meta-analysis on the relation between acute stress, alcohol consumption and cortisol levels in individuals with a personal, familial or no alcohol use disorder.Translational psychiatry · 2025Pooled it
- An Overview of Appetite-Regulatory Peptides in Addiction Processes; From Bench to Bed Side.Frontiers in neuroscience · 2021Pooled it
- Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis.Addiction biology · 2019Pooled it
- Evaluation of glycine treatment for reducing alcohol craving and self-administration in individuals with alcohol use disorder: A human laboratory trial.Alcohol, clinical & experimental research · 2025Trial
- Aversion-resistant alcohol seeking in the human laboratory.Alcohol, clinical & experimental research · 2025Trial
- Across the spectrum: Acute alcohol responses in young adults with mild, moderate, and severe alcohol use disorder.Drug and alcohol dependence · 2025Trial
- Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Self-report assessment of alcohol sensitivity: An examination of the effects of different probes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Trial
- Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study.Psychopharmacology · 2023Trial
- Differential effects of UPPS-P impulsivity on subjective alcohol response and craving: An experimental test of acquired preparedness.Experimental and clinical psychopharmacology · 2023Trial
- The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior.Experimental and clinical psychopharmacology · 2022Trial
- Acute alcohol rewarding effects as a risk factor for hangover frequency.Addictive behaviors · 2022Trial
- Within- and between-person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation.Alcoholism, clinical and experimental research · 2022Trial
- Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli.Alcoholism, clinical and experimental research · 2022Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Alcohol subjective responses in heavy drinkers: Measuring acute effects in the natural environment versus the controlled laboratory setting.Alcoholism, clinical and experimental research · 2021Trial
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
- Striatal activation to monetary reward is associated with alcohol reward sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
109 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
backgroundPropensity for alcohol misuse may be linked to an individuals' response to alcohol. This study examined the role of alcohol response phenotypes to future drinking problems.
methodsOne hundred four young heavy social drinkers participated in a within-subject, double-blind, placebo-controlled laboratory alcohol challenge study with 6-year follow-up. Participants were examined for subjective responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beverage, given in random order. Follow-up was conducted in 5 waves over 6 years after the sessions to assess drinking behaviors and alcohol use disorder (AUD) symptoms. Retention was high with 98% (509 of 520) of possible follow-ups completed.
resultsGreater sensitivity to alcohol, in terms of stimulation and rewarding effects (like, want more) and lower sensitivity to alcohol sedation predicted greater number of AUD symptoms through 6 years of follow-up. Cluster analyses revealed that for half the sample, increasing levels of stimulation and liking were predictors of more AUD symptoms with the other half divided between those showing like and want more and want more alone as significant predictors.
conclusionsThe findings extend previous findings and offer new empirical insights into the propensity for excessive drinking and alcohol problems. Heightened alcohol stimulation and reward sensitivity robustly predicted more alcohol use disorder symptoms over time associated with greater binge-drinking frequency. These drinking problems were maintained and progressed as these participants were entering their third decade of life, a developmental interval when continued alcohol misuse becomes more deviant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.