Evidence map›Paper›PMID 24094568›Full record

SynthesisGeneral hospital psychiatry

A meta-analysis of the relationship between antidepressant use in pregnancy and the risk of preterm birth and low birth weight.

Hsiang Huang, Shane Coleman, Jeffrey A Bridge, Kimberly Yonkers, Wayne Katon

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  6. [Association between depression during pregnancy and low birth weight in neonates: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
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  18. Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling.American journal of physiology. Heart and circulatory physiology · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hsiang HuangDepartment of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA. Electronic address: hhuang@cha.harvard.edu.
Shane ColemanDepartment of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA.
Jeffrey A BridgeDepartment of Pediatrics and The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Kimberly YonkersPMS and Perinatal Psychiatric Research Program, Yale University, New Haven, CT, USA.
Wayne KatonDepartment of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA.

Funding

Psychiatry Primary Care NRSA T-32 AwardT32MH020021 · NIMH · UNIVERSITY OF WASHINGTON · PI JOHN C. FORTNEY, JURGEN UNUTZER · 1998 to 2026
$5.6M
NIMH NIH HHS T32 MH020021NIMH NIH HHS T32 MH20021-14
6 · The paper itself

Abstract

objectivesTo examine the relationship between antidepressant use in pregnancy and low birth weight (LBW) and preterm birth (PTB). DATA SOURCES AND STUDY SELECTION: We searched English and non-English language articles via PubMed, CINAHL and PsychINFO (from their start dates through December 1st, 2012). We used the following keywords and their combinations: antidepressant, selective serotonin reuptake inhibitor (SSRI), pregnancy, antenatal, prenatal, birthweight, birth weight, preterm, prematurity, gestational age, fetal growth restriction, intrauterine growth restriction, and small-for-gestational age. Published studies were considered eligible if they examined exposure to antidepressant medication use during pregnancy and reported data on at least one birth outcome of interest: PTB (<37 weeks gestation) or LBW (<2500 g). Of the 222 reviewed studies, 28 published studies met the selection criteria. DATA EXTRACTION: Two authors independently extracted study characteristics from eligible studies.

resultsUsing random-effects models, antidepressant use in pregnancy was significantly associated with LBW (RR: 1.44, 95% confidence interval (CI): 1.21-1.70) and PTB (RR: 1.69, 95% CI: 1.52-1.88). Studies varied widely in design, populations, control groups and methods. There was a high level of heterogeneity as measured by I2 statistics for both outcomes examined. The relationship between antidepressant exposure in pregnancy and adverse birth outcomes did not differ significantly when taking into account drug type (SSRI vs. other or mixed) or study design (prospective vs. retrospective). There was a significant association between antidepressant exposure and PTB for different types of control status used (depressed, mixed or nondepressed).

conclusionsAntidepressant use during pregnancy significantly increases the risk for LBW and PTB.

Indexed as

Infant, Low Birth WeightPremature BirthAntidepressive AgentsDepressive DisorderFemaleHumansInfant, NewbornPregnancyPregnancy ComplicationsPregnancy OutcomeTreatment OutcomeAntidepressive AgentsAdverse birth outcomesAntenatalAntidepressantsLow birth weightPregnancyPrenatalPreterm birth

Identifiers

PMID24094568
PMCPMC3877723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.