ArticleBiophysical journal2013
Interactions between fengycin and model bilayers quantified by coarse-grained molecular dynamics.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- An EndophyticJournal of fungi (Basel, Switzerland) · 2026Article
- Non-aerated compost extracts: optimizing fermentation for enhanced antifungal effects against phytopathogenic fungi.Scientific reports · 2026Article
- Two promising natural lipopeptides fromActa biochimica Polonica · 2024Article
- Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs.Antiviral research · 2023Article
- Purification of lipopeptide biosurfactant extracts obtained from a complex residual food stream using Tricine-SDS-PAGE electrophoresis.Frontiers in bioengineering and biotechnology · 2023Article
- Organizations of melittin peptides after spontaneous penetration into cell membranes.Biophysical journal · 2022Article
- Effects of cholesterol on the mechanism of fengycin, a biofungicide.Biophysical journal · 2022Article
- Listeria monocytogenes exposed to antimicrobial peptides displays differential regulation of lipids and proteins associated to stress response.Cellular and molecular life sciences : CMLS · 2022Article
- Semi-synthetic puwainaphycin/minutissamide cyclic lipopeptides with improved antifungal activity and limited cytotoxicity.RSC advances · 2021Article
- Efficacy of cyclic lipopeptides obtained fromHeliyon · 2021Article
- Role of Lipid Composition in the Interaction and Activity of the Antimicrobial Compound Fengycin with Complex Membrane Models.The Journal of membrane biology · 2019Article
- Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes.Scientific reports · 2019Article
- Role of Lipid Composition, Physicochemical Interactions, and Membrane Mechanics in the Molecular Actions of Microbial Cyclic Lipopeptides.The Journal of membrane biology · 2019Review
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Fengycins FromFrontiers in microbiology · 2019Article
- Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics.The journal of physical chemistry. B · 2018Article
- Computational studies of peptide-induced membrane pore formation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Vesicle Leakage Reflects the Target Selectivity of Antimicrobial Lipopeptides from Bacillus subtilis.Biophysical journal · 2015Article
- Article
- Additive and synergistic membrane permeabilization by antimicrobial (lipo)peptides and detergents.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bacteria, particularly of the genus Bacillus, produce a wide variety of antifungal compounds. They act by affecting the lipid bilayers of fungal membranes, causing curvature-induced strain and eventual permeabilization. One class of these, known as fengycins, has been commercialized for treating agricultural infections and shows some promise as a possible antifungal pharmaceutical. Understanding the mechanism by which fengycins damage lipid bilayers could prove useful to the future development of related antifungal treatments. In this work, we present multi-microsecond-long simulations of fengycin interacting with different lipid bilayer systems. We see fengycin aggregation and uncover a clear aggregation pattern that is partially influenced by bilayer composition. We also quantify some local bilayer perturbations caused by fengycin binding, including curvature of the lipid bilayer and local electrostatic-driven reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.