ArticleEvolution; international journal of organic evolution2013
Successive gain of insulator proteins in arthropod evolution.
Article in Evolution; international journal of organic evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer.Genome biology and evolution · 2025Review
- Chromosome structure ineLife · 2024Article
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- Unique territorial and compartmental organization of chromosomes in the holocentric silkmoth.Research square · 2024Article
- Single-nucleus RNA-sequencing in pre-cellularization Drosophila melanogaster embryos.PloS one · 2022Article
- Insights into HP1a-Chromatin Interactions.Cells · 2020Review
- The genetic factors of bilaterian evolution.eLife · 2020Article
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- Function and regulation of chromatin insulators in dynamic genome organization.Current opinion in cell biology · 2019Review
- Evolution of the Drosophila melanogaster Chromatin Landscape and Its Associated Proteins.Genome biology and evolution · 2019Article
- ChIP-ping the branches of the tree: functional genomics and the evolution of eukaryotic gene regulation.Briefings in functional genomics · 2018Review
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- Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects : Insect insulator proteins.BMC genomics · 2016Article
- Suppressor of hairy-wing, modifier of mdg4 and centrosomal protein of 190 gene orthologues of the gypsy insulator complex in the malaria mosquito, Anopheles stephensi.Insect molecular biology · 2016Article
- The insulator protein BEAF-32 is required for Hippo pathway activity in the terminal differentiation of neuronal subtypes.Development (Cambridge, England) · 2016Article
- Gains and Losses of Transcription Factor Binding Sites in Saccharomyces cerevisiae and Saccharomyces paradoxus.Genome biology and evolution · 2015Article
- Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function.Cellular and molecular life sciences : CMLS · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alteration of regulatory DNA elements or their binding proteins may have drastic consequences for morphological evolution. Chromatin insulators are one example of such proteins and play a fundamental role in organizing gene expression. While a single insulator protein, CTCF (CCCTC-binding factor), is known in vertebrates, Drosophila melanogaster utilizes six additional factors. We studied the evolution of these proteins and show here that-in contrast to the bilaterian-wide distribution of CTCF-all other D. melanogaster insulators are restricted to arthropods. The full set is present exclusively in the genus Drosophila whereas only two insulators, Su(Hw) and CTCF, existed at the base of the arthropod clade and all additional factors have been acquired successively at later stages. Secondary loss of factors in some lineages further led to the presence of different insulator subsets in arthropods. Thus, the evolution of insulator proteins within arthropods is an ongoing and dynamic process that reshapes and supplements the ancient CTCF-based system common to bilaterians. Expansion of insulator systems may therefore be a general strategy to increase an organism's gene regulatory repertoire and its potential for morphological plasticity.
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