ArticleEvolution; international journal of organic evolution2013
The evolution of hybrid incompatibilities along a phylogeny.
Article in Evolution; international journal of organic evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- Male sterility in Drosophila hybrids revealed by a multi-generational transcriptomic analysis of genes and transposable elements in testes.BMC biology · 2026Article
- Admixture Mapping Reveals Evidence for Multiple Mitonuclear Incompatibilities in Swordtail Fish Hybrids.Molecular ecology · 2025Article
- Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids.G3 (Bethesda, Md.) · 2022Article
- Predictability and parallelism in the contemporary evolution of hybrid genomes.PLoS genetics · 2022Article
- Speciation genes are more likely to have discordant gene trees.Evolution letters · 2018Article
- Article
- Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies inGenetics · 2017Review
- Darwinism for the Genomic Age: Connecting Mutation to Diversification.Frontiers in genetics · 2017Article
- The Pace of Hybrid Incompatibility Evolution in House Mice.Genetics · 2015Article
- Hybrid breakdown in cichlid fish.PloS one · 2015Article
- Interspecific tests of allelism reveal the evolutionary timing and pattern of accumulation of reproductive isolation mutations.PLoS genetics · 2014Article
- Estimating the duration of speciation from phylogenies.Evolution; international journal of organic evolution · 2014Article
- Macroevolutionary speciation rates are decoupled from the evolution of intrinsic reproductive isolation in Drosophila and birds.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The Dobzhansky-Muller model of speciation posits that defects in hybrids between species are the result of negative epistatic interactions between alleles that arose in independent genetic backgrounds. Tests of one important prediction from this model, that incompatibilities "snowball," have relied on comparisons of the number of incompatibilities between closely related pairs of species separated by different divergence times. How incompatibilities accumulate along phylogenies, however, remains poorly understood. We extend the Dobzhansky-Muller model to multispecies clades to describe the mathematical relationship between tree topology and the number of shared incompatibilities among related pairs of species. We use these results to develop a statistical test that distinguishes between the snowball and alternative incompatibility accumulation models, including nonepistatic and multilocus incompatibility models, in a phylogenetic context. We further demonstrate that patterns of incompatibility sharing across species pairs can be used to estimate the relative frequencies of different types of incompatibilities, including derived-derived versus derived-ancestral incompatibilities. Our results and statistical methods should motivate comparative genetic mapping of hybrid incompatibilities to evaluate competing models of speciation.
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