ArticleBMC genomics2013
DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.BMC medical genomics · 2015Pooled it
- Trial
- Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026Review
- Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies.Clinical epigenetics · 2025Article
- Cryopreservation, cryoprotectants, and potential risk of epigenetic alteration.Journal of assisted reproduction and genetics · 2024Review
- Reprogramming mechanism dissection and trophoblast replacement application in monkey somatic cell nuclear transfer.Nature communications · 2024Article
- Can Cryopreservation in Assisted Reproductive Technology (ART) Induce Epigenetic Changes to Gametes and Embryos?Journal of clinical medicine · 2023Review
- Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines.Clinical epigenetics · 2022Article
- Selective chemical tracking of Dnmt1 catalytic activity in live cells.Molecular cell · 2022Article
- Imprinted Genes and Multiple Sclerosis: What Do We Know?International journal of molecular sciences · 2021Review
- Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life.Scientific reports · 2021Article
- Cell-specific characterization of the placental methylome.BMC genomics · 2021Article
- Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.PLoS genetics · 2019Review
- A genome-wide search for new imprinted genes in the human placenta identifies DSCAM as the first imprinted gene on chromosome 21.European journal of human genetics : EJHG · 2019Article
- Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling.PLoS genetics · 2018Article
- AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination.Nature communications · 2017Article
- Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.Genome biology · 2017Review
- A complex association between DNA methylation and gene expression in human placenta at first and third trimesters.PloS one · 2017Article
- Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta.American journal of human genetics · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGenomic imprinting is an epigenetically regulated process wherein genes are expressed in a parent-of-origin specific manner. Many imprinted genes were initially identified in mice; some of these were subsequently shown not to be imprinted in humans. Such discrepancy reflects developmental, morphological and physiological differences between mouse and human tissues. This is particularly relevant for the placenta. Study of genomic imprinting thus needs to be carried out in a species and developmental stage-specific manner. We describe here a new strategy to study allele-specific DNA methylation in the human placenta for the discovery of novel imprinted genes.
resultsUsing this methodology, we confirmed 16 differentially methylated regions (DMRs) associated with known imprinted genes. We chose 28 genomic regions for further testing and identified two imprinted genes (DNMT1 and AIM1). Both genes showed maternal allele-specific methylation and paternal allele-specific transcription. Imprinted expression for AIM1 was conserved in the cynomolgus macaque placenta, but not in other macaque tissues or in the mouse.
conclusionsOur study indicates that while there are many genomic regions with allele-specific methylation in tissues like the placenta, only a small sub-set of them are associated with allele-specific transcription, suggesting alternative functions for such genomic regions. Nonetheless, novel tissue-specific imprinted genes remain to be discovered in humans. Their identification may help us better understand embryonic and fetal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.