Evidence map›Paper›PMID 24094134›Full record

ArticleBMC medical informatics and decision making2013

Evaluating the risk of patient re-identification from adverse drug event reports.

Khaled El Emam, Fida K Dankar, Angelica Neisa, Elizabeth Jonker

Abstract read
In one paragraph

Article in BMC medical informatics and decision making, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Identifying family structures from obituaries and matching them to patients in an electronic heath record.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  3. [Re-identification potential of structured health data].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024
    Review
  4. Article
  5. Article
  6. Generating sequential electronic health records using dual adversarial autoencoder.Journal of the American Medical Informatics Association : JAMIA · 2020
    Article
  7. Protecting Privacy When Sharing and Releasing Data with Multiple Records per Person.Journal of the Association for Information Systems · 2020
    Article
  8. Differential Privacy for the Vast Majority.ACM transactions on management information systems · 2019
    Article
  9. Article
  10. Informed Consent in Biomedical Research.Computational and structural biotechnology journal · 2019
    Review
  11. Review
  12. Article
  13. Anonymising and sharing individual patient data.BMJ (Clinical research ed.) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khaled El EmamChildren's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario, K1J 8 L1, Canada. kelemam@uottawa.ca.
Fida K Dankar
Angelica Neisa
Elizabeth Jonker

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundOur objective was to develop a model for measuring re-identification risk that more closely mimics the behaviour of an adversary by accounting for repeated attempts at matching and verification of matches, and apply it to evaluate the risk of re-identification for Canada's post-marketing adverse drug event database (ADE).Re-identification is only demonstrably plausible for deaths in ADE. A matching experiment between ADE records and virtual obituaries constructed from Statistics Canada vital statistics was simulated. A new re-identification risk is considered, it assumes that after gathering all the potential matches for a patient record (all records in the obituaries that are potential matches for an ADE record), an adversary tries to verify these potential matches. Two adversary scenarios were considered: (a) a mildly motivated adversary who will stop after one verification attempt, and (b) a highly motivated adversary who will attempt to verify all the potential matches and is only limited by practical or financial considerations.

methodsThe mean percentage of records in ADE that had a high probability of being re-identified was computed.

resultsUnder scenario (a), the risk of re-identification from disclosing the province, age at death, gender, and exact date of the report is quite high, but the removal of province brings down the risk significantly. By only generalizing the date of reporting to month and year and including all other variables, the risk is always low. All ADE records have a high risk of re-identification under scenario (b), but the plausibility of that scenario is limited because of the financial and practical deterrent even for highly motivated adversaries.

conclusionsIt is possible to disclose Canada's adverse drug event database while ensuring that plausible re-identification risks are acceptably low. Our new re-identification risk model is suitable for such risk assessments.

Indexed as

ConfidentialityAdverse Drug Reaction Reporting SystemsCanadaHumansRisk Assessment

Identifiers

PMID24094134
PMCPMC4137558

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.