Evidence map›Paper›PMID 24094120›Full record

ArticleThe journal of spinal cord medicine2013

Lower extremity functional electrical stimulation cycling promotes physical and functional recovery in chronic spinal cord injury.

Cristina L Sadowsky, Edward R Hammond, Adam B Strohl, Paul K Commean, Sarah A Eby, Diane L Damiano, Jason R Wingert, Kyongtae T Bae, John W McDonald

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05975606 (Exploring the Effect of Non-invasive Brain Stimulation Paired With Functional Electrical Stimulation to Improve Lower Extremity Function Following Incomplete Spinal Cord Injury), which is not on this map. Cited by 44 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05975606 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Exploring the Effect of Non-invasive Brain Stimulation Paired With Functional Electrical Stimulation to Improve Lower Extremity Function Following Incomplete Spinal Cord Injury

TypeinterventionalSponsorWestern University, CanadaRan2023 to 2025Enrolled14ConditionsIncomplete Spinal Cord InjuryArmsrepetitive transcranial magnetic stimulation (rTMS), functional electrical stimulation (FES) cycling
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  12. Effectiveness of Functional Electrical Stimulation - Cycling Treatment in Children with Cerebral Palsy.Malawi medical journal : the journal of Medical Association of Malawi · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristina L SadowskyThe International Center for Spinal Cord Injury and the Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA; and Department of Physical Medicine and Rehabilitation, Department of Neurology (JWM), John Hopkins, Baltimore, MD USA.
Edward R HammondThe International Center for Spinal Cord Injury and the Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
Adam B StrohlDivision of Plastic and Reconstructive Surgery, Mount Sinai Medical Center, NY, USA.
Paul K CommeanMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Sarah A EbyDepartment of Physical Medicine and Rehabilitation, Sinai Hospital, Baltimore, MD, USA.
Diane L DamianoNational Institutes of Health, Bethesda, MD, USA.
Jason R WingertDepartment of Health and Wellness, University of North Carolina, Asheville, NC, USA.
Kyongtae T BaeDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
John W McDonaldThe International Center for Spinal Cord Injury and the Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA; and Department of Neurology, Neurological Surgery, Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA.

Funding

Intramural NIH HHS
6 · The paper itself

Abstract

objectiveTo examine the effect of long-term lower extremity functional electrical stimulation (FES) cycling on the physical integrity and functional recovery in people with chronic spinal cord injury (SCI).

designRetrospective cohort, mean follow-up 29.1 months, and cross-sectional evaluation.

settingWashington University Spinal Cord Injury Neurorehabilitation Center, referral center.

participantsTwenty-five people with chronic SCI who received FES during cycling were matched by age, gender, injury level, and severity, and duration of injury to 20 people with SCI who received range of motion and stretching.

interventionLower extremity FES during cycling as part of an activity-based restorative treatment regimen.

main outcome measureChange in neurological function: motor, sensory, and combined motor-sensory scores (CMSS) assessed by the American Spinal Injury Association Impairment scale. Response was defined as ≥ 1 point improvement.

resultsFES was associated with an 80% CMSS responder rate compared to 40% in controls. An average 9.6 CMSS point loss among controls was offset by an average 20-point gain among FES subjects. Quadriceps muscle mass was on average 36% higher and intra/inter-muscular fat 44% lower, in the FES group. Hamstring and quadriceps muscle strength was 30 and 35% greater, respectively, in the FES group. Quality of life and daily function measures were significantly higher in FES group.

conclusionFES during cycling in chronic SCI may provide substantial physical integrity benefits, including enhanced neurological and functional performance, increased muscle size and force-generation potential, reduced spasticity, and improved quality of life.

Indexed as

Recovery of FunctionAdultCross-Sectional StudiesElectric Stimulation TherapyExercise TherapyFemaleHumansLower ExtremityMaleMuscle, SkeletalMuscle SpasticityMuscle StrengthRetrospective StudiesSpinal Cord Injuries

Identifiers

PMID24094120
PMCPMC3831323

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.