ArticleNeuron2013
A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Attenuation of social preference and alteration of cortical neurons following adolescent cerebellar nuclei perturbation.Molecular psychiatry · 2026Article
- Developmental disinhibition gates language lateralization in childhood.Nature communications · 2026Article
- Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response.Molecular psychiatry · 2026Article
- Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations.Molecular psychiatry · 2026Article
- Spatial heterogeneity and subtypes of functional connectivity development in youth.Nature communications · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- ESMR: a process framework for calibration dynamics across psychosomatic and psychiatric phenomena.Frontiers in psychiatry · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- The effective connectome over a century of human life.Communications biology · 2025Article
- Comparative Neuroplasticity in Frontal- and Lateral-Eyed Mammals With Induced-Binocular Vision Dysfunction: Insights From Monocular Deprivation Models.The European journal of neuroscience · 2025Review
- Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling.Science advances · 2025Article
- Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory.Developmental cognitive neuroscience · 2025Article
- Article
- Rapid and cumulative adult plasticity in the mouse visual cortex.Frontiers in neural circuits · 2025Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.iScience · 2024Article
- Revisiting adolescence as a sensitive period for sociocultural processing.Neuroscience and biobehavioral reviews · 2024Review
- Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio.bioRxiv : the preprint server for biology · 2024Article
- In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
What causes critical periods (CPs) to open? For the best-studied case, ocular dominance plasticity in primary visual cortex in response to monocular deprivation (MD), the maturation of inhibition is necessary and sufficient. How does inhibition open the CP? We present a theory: the transition from pre-CP to CP plasticity arises because inhibition preferentially suppresses responses to spontaneous relative to visually driven input activity, switching learning cues from internal to external sources. This differs from previous proposals in (1) arguing that the CP can open without changes in plasticity mechanisms when activity patterns become more sensitive to sensory experience through circuit development, and (2) explaining not simply a transition from no plasticity to plasticity, but a change in outcome of MD-induced plasticity from pre-CP to CP. More broadly, hierarchical organization of sensory-motor pathways may develop through a cascade of CPs induced as circuit maturation progresses from "lower" to "higher" cortical areas.
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