ReviewAmerican heart journal2013
Learning from recent trials and shaping the future of acute heart failure trials.
Review in American heart journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Risk stratification scores for patients with acute heart failure in the Emergency Department: A systematic review.European heart journal. Acute cardiovascular care · 2020Pooled it
- Trial
- Hypertension and Heart Failure: From Pathophysiology to Treatment.International journal of molecular sciences · 2024Review
- Neurohumoral Activation in Heart Failure.International journal of molecular sciences · 2023Review
- Phase II Trials in Drug Development and Adaptive Trial Design.JACC. Basic to translational science · 2019Article
- The effect of emphysema on readmission and survival among smokers with heart failure.PloS one · 2018Article
- Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New?Current heart failure reports · 2017Review
- Win Ratio -An Intuitive and Easy-To-Interpret Composite Outcome in Medical Studies.Shanghai archives of psychiatry · 2017Article
- Acute heart failure facts and numbers: acute heart failure populations.ESC heart failure · 2016Article
- Pathophysiology and clinical evaluation of acute heart failure.Nature reviews. Cardiology · 2016Review
- COPD in heart failure: are there long-term implications following acute heart failure hospitalization?Chest · 2015Article
- Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction.Journal of the American College of Cardiology · 2014Review
- Persistent angina pectoris in ischaemic cardiomyopathy: increased rehospitalization and major adverse cardiac events.European journal of heart failure · 2014Article
- Arrhythmogenic right ventricular dysplasia back in force.The American journal of cardiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
The last decade of acute heart failure (HF) research is characterized by disappointments in large phase 2 and 3 pharmacologic studies of therapeutics including calcium-sensitizing agents and antagonists of endothelin, vasopressin, and adenosine. As a result, pharmacologic management for acute HF has changed little in recent years, and adverse event rates remain higher than in chronic HF. Despite neutral results in many acute HF trials, recent studies including RELAX-AHF, ASTRONAUT, and PRONTO have highlighted the role of appropriate timing of patient enrollment, targeting the "right" patients, and selecting appropriate end points and sites. We describe lessons learned from recent trials in acute HF and outline strategies to improve the potential for success in future trials. This review is based on discussions between scientists, clinical trialists, and regulatory representatives at the 9th Global Cardio Vascular Clinical Trialists Forum in Paris, France, from November 30 to December 1, 2012.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.