ArticleTissue engineering. Part A2014
Biomimetic-engineered poly (ethylene glycol) hydrogel for smooth muscle cell migration.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Tunable Bicontinuous Macroporous Cell Culture Scaffolds via Kinetically Controlled Phase Separation.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Physical and Bioactive Properties of Glycosaminoglycan Hydrogels Modulated by Polymer Design Parameters and Polymer Ratio.Biomacromolecules · 2021Article
- Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs.Tissue engineering. Part B, Reviews · 2017Review
- Three-dimensional fabrication of cell-laden biodegradable poly(ethylene glycol-Journal of materials chemistry. B · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We report on a biomimetic scaffold as a model system to evaluate smooth muscle cell (SMC) migration in three dimensions. To accomplish this, bio-inert poly (ethylene glycol) (PEG)-based hydrogels were designed as the scaffold substrate. To mimic properties of the extracellular matrix, cell-adhesive peptide (GRGDSP) derived from fibronectin and collagenase-sensitive peptide (GPQGIAGQ) derived from collagen type I were incorporated into the PEG macromer chain. Copolymerization of the biomimetic macromers results in the formation of bioactive PEG hydrogels with cell adhesivity and biodegradability. By utilizing these biomimetic scaffolds, we studied the effect of adhesive ligand concentration, proteolysis, and network cross-linking density on cell migration. Our results showed that three-dimensional SMC migration has a biphasic dependence on adhesive ligand density, and both adhesive and collagenase-sensitive peptides were required for cell migration to occur. Furthermore, network cross-linking density was shown to dramatically influence the behavior of cell migration in the hydrogels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.