ArticleMalaria journal2013
Genetic structure of Plasmodium falciparum populations across the Honduras-Nicaragua border.
Article in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- One Health in Mesoamerica: historical legacies, current challenges, and strategic directions.One health outlook · 2026Article
- Genetic diversity and population structure of Plasmodium falciparum across areas of varied malaria transmission intensities in Uganda.Malaria journal · 2025Article
- Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2025Article
- Molecular epidemiology of continuedFrontiers in tropical diseases · 2023Article
- Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon.Scientific reports · 2022Article
- Molecular Characteristics and Genetic Diversity ofJournal of veterinary research · 2022Article
- RecurrentInternational journal of environmental research and public health · 2022Article
- Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.PloS one · 2022Article
- Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya.Frontiers in genetics · 2022Article
- Evidence of a Recent Bottleneck inPathogens (Basel, Switzerland) · 2021Article
- Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis.Malaria journal · 2021Article
- Genomic surveillance of Plasmodium falciparum and Plasmodium vivax cases at the University Hospital in Tegucigalpa, Honduras.Scientific reports · 2020Article
- High Genetic Diversity of Plasmodium falciparum in the Low-Transmission Setting of the Kingdom of Eswatini.The Journal of infectious diseases · 2019Article
- Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity ofAfrican health sciences · 2019Article
- Diverse origin of Plasmodium falciparum in northwest Ecuador.Malaria journal · 2019Article
- Malaria Molecular Epidemiology: An Evolutionary Genetics Perspective.Microbiology spectrum · 2019Review
- Genetic diversity and natural selection of Plasmodium vivax multi-drug resistant gene (pvmdr1) in Mesoamerica.Malaria journal · 2017Article
- Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.Molecular ecology · 2017Article
- Genetic Diversity and Population Structure of Plasmodium falciparum in Lake Victoria Islands, A Region of Intense Transmission.The American journal of tropical medicine and hygiene · 2016Article
- Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens.Veterinary parasitology · 2016Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Caribbean coast of Central America remains an area of malaria transmission caused by Plasmodium falciparum despite the fact that morbidity has been reduced in recent years. Parasite populations in that region show interesting characteristics such as chloroquine susceptibility and low mortality rates. Genetic structure and diversity of P. falciparum populations in the Honduras-Nicaragua border were analysed in this study.
methodsSeven neutral microsatellite loci were analysed in 110 P. falciparum isolates from endemic areas of Honduras (n = 77) and Nicaragua (n = 33), mostly from the border region called the Moskitia. Several analyses concerning the genetic diversity, linkage disequilibrium, population structure, molecular variance, and haplotype clustering were conducted.
resultsThere was a low level of genetic diversity in P. falciparum populations from Honduras and Nicaragua. Expected heterozigosity (H(e)) results were similarly low for both populations. A moderate differentiation was revealed by the F(ST) index between both populations, and two putative clusters were defined through a structure analysis. The main cluster grouped most of samples from Honduras and Nicaragua, while the second cluster was smaller and included all the samples from the Siuna community in Nicaragua. This result could partially explain the stronger linkage disequilibrium (LD) in the parasite population from that country. These findings are congruent with the decreasing rates of malaria endemicity in Central America.
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