Evidence map›Paper›PMID 24093080›Full record

ArticleCurrent translational geriatrics and experimental gerontology reports2013

Treatment of Alzheimer's Disease: Current Management and Experimental Therapeutics.

Lawrence S Honig, Clara D Boyd

Abstract read
In one paragraph

Article in Current translational geriatrics and experimental gerontology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Sinomenine Hydrochloride Impedes Memory Impairments via Nrf2/HO-1-Mediated Inhibition of Oxidative Stress, Neuroinflammation and Apoptosis in Mice Brain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  2. Article
  3. Review
  4. Neuroactive Phytoconstituents ofCurrent topics in medicinal chemistry · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lawrence S HonigTaub Institute for Research in Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Medical Center, Phone Number: 212-305-9194, Fax Number: 212-305-2526, Address: G. H. Sergievsky Center (P&S Unit 16), 630 West 168 St., New York, NY 10032.
Clara D Boyd

Funding

Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
ZOLEDRONIC ACID IN PROSTATE CANCERM01RR000645 · NCRR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COLTEN, HARVEY R · 1985 to 2006
$27.0M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITYR01AG018732 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD · 2000 to 2002
$2.3M
NCRR NIH HHS M01 RR000645NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG018732NIA NIH HHS U01 AG023749
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a major cause of morbidity in the elderly. AD affects aver 5 million persons in the United States, but because it increases in incidence in the elderly, and the "graying" population, AD is projected to increase in prevalence by many-fold over the coming decades. AD causes progressive mental impairment, resulting in the inability of persons to care for themselves. As a consequence, AD results in enormous costs to society due to both lost productivity, and required care. Thus, improved management and treatment is essential. In this review we will briefly review current understanding of the disease, including roles of beta-amyloid and tau proteins. We will then discuss current therapies in use, including the evidence for treatments with supplements, established drugs, and investigational therapeutic strategies, recently completed and ongoing.

Indexed as

Alzheimer’s diseaseAmyloidAnti-amyloidBeta-amyloidBeta-secretaseCholinesteraseDementiaElderlyExperimental therapeuticsGamma-secretaseMonoclonal antibodyPhosphotauSecretaseTauTreatment

Identifiers

PMID24093080
PMCPMC3786221

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.