ArticleFrontiers in human neuroscience2013
Environmental enrichment may protect against hippocampal atrophy in the chronic stages of traumatic brain injury.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Scale of Neurodegeneration in Moderate-to-Severe Traumatic Brain Injury: A Systematic Review of Longitudinal Studies.Annals of neurology · 2025Pooled it
- Implementation of active injury management (AIM) in youth with acute concussion: A randomized controlled trial.Contemporary clinical trials · 2022Trial
- Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury.Neural plasticity · 2021Trial
- Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating.Annals of clinical and translational neurology · 2026Article
- Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cognitive efficacy and neural mechanisms of music-based neurological rehabilitation for traumatic brain injury.Annals of the New York Academy of Sciences · 2022Review
- Sex-dependent effects of postweaning exposure to an enriched environment on visceral pain and anxiety- and depression-like behaviors induced by neonatal maternal separation.Translational pediatrics · 2022Article
- Patterns of change in cortical morphometry following traumatic brain injury in adults.Human brain mapping · 2022Article
- Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise.Social neuroscience · 2021Article
- Environmental enrichment: A concept analysis.Nursing forum · 2021Article
- The scale of neurodegeneration in moderate-to-severe traumatic brain injury: a systematic review protocol.Systematic reviews · 2019Article
- Socioeconomic status and hippocampal volume in children and young adults.Developmental science · 2018Article
- Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury.Journal of neuroscience research · 2018Article
- Role of early environmental enrichment on the social dominance tube test at adulthood in the rat.Psychopharmacology · 2017Article
- Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation.Addiction biology · 2017Article
- An enriched environment and 17-beta estradiol produce similar pro-cognitive effects on ovariectomized rats.Cognitive processing · 2016Article
- Environmental enrichment and abstinence attenuate ketamine-induced cardiac and renal toxicity.Scientific reports · 2015Article
- Editorial: Brain Injury as a Neurodegenerative Disorder.Frontiers in human neuroscience · 2015Article
- Negative neuroplasticity in chronic traumatic brain injury and implications for neurorehabilitation.Neuropsychology review · 2014Review
- Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury.Frontiers in systems neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the relationship between environmental enrichment (EE) and hippocampal atrophy in the chronic stages of moderate to severe traumatic brain injury (TBI).
designRetrospective analysis of prospectively collected data; observational, within-subjects.
participantsPatients (N = 25) with moderate to severe TBI. MEASURES: Primary predictors: (1) An aggregate of self-report rating of EE (comprising hours of cognitive, physical, and social activities) at 5 months post-injury; (2) pre-injury years of education as a proxy for pre-morbid EE (or cognitive reserve). PRIMARY OUTCOME: bilateral hippocampal volume change from 5 to 28 months post-injury.
resultsAs predicted, self-reported EE was significantly negatively correlated with bilateral hippocampal atrophy (p < 0.05), with greater EE associated with less atrophy from 5 to 28 months. Contrary to prediction, years of education (a proxy for cognitive reserve) was not significantly associated with atrophy.
conclusionPost-injury EE may serve as a buffer against hippocampal atrophy in the chronic stages of moderate-severe TBI. Clinical application of EE should be considered for optimal maintenance of neurological functioning in the chronic stages of moderate-severe TBI.
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Registered trials
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