Evidence map›Paper›PMID 24092932›Full record

ReviewBlood2013

Inflammation, obesity, and thrombosis.

Fahumiya Samad, Wolfram Ruf

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 7 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 7 syntheses or guidelines pooled it, 396 citations in OpenAlex.

  1. Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  4. Metabolic Disorders and Risk of Portal Vein Thrombosis in Liver Cirrhosis: A Systematic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
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  8. Prognostic impact of body mass index in acute myocardial infarction complicated by cardiogenic Shock: an ECLS-SHOCK subanalysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Fahumiya SamadDepartment of Cell Biology, Torrey Pines Institute for Molecular Studies, San Diego, CA; and.
Wolfram Ruf
Scripps Research Institute · USTorrey Pines Institute For Molecular Studies · US

Funding

THROMBUS FORMATION IN BABOONSP01HL031950 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H · 1985 to 2015
$29.4M
TF Signaling in Systemic InflammationR01HL077753 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUF, WOLFRAM · 2004 to 2011
$3.6M
Therapeutic Opportunities of Targeting Tissue Factor Signaling in ObesityR01HL104232 · NHLBI · TORREY PINES INST FOR MOLECULAR STUDIES · PI SAMAD, FAHUMIYA · 2011 to 2014
$2.4M
Ceramide and cardiovascular risk in obesityR01HL071146 · NHLBI · TORREY PINES INST FOR MOLECULAR STUDIES · PI SAMAD, FAHUMIYA · 2004 to 2008
$2.2M
NHLBI NIH HHS HL104232NHLBI NIH HHS HL31950NHLBI NIH HHS HL71146NHLBI NIH HHS HL77753NHLBI NIH HHS P01 HL031950NHLBI NIH HHS R01 HL071146NHLBI NIH HHS R01 HL077753NHLBI NIH HHS R01 HL104232
6 · The paper itself

Abstract

Clinical and epidemiological studies support a connection between obesity and thrombosis, involving elevated expression of the prothrombotic molecules plasminogen activator inhibitor-1 and tissue factor (TF) and increased platelet activation. Cardiovascular diseases and metabolic syndrome-associated disorders, including obesity, insulin resistance, type 2 diabetes, and hepatic steatosis, involve inflammation elicited by infiltration and activation of immune cells, particularly macrophages, into adipose tissue. Although TF has been clearly linked to a procoagulant state in obesity, emerging genetic and pharmacologic evidence indicate that TF signaling via G protein-coupled protease-activated receptors (PAR2, PAR1) additionally drives multiple aspects of the metabolic syndrome. TF-PAR2 signaling in adipocytes contributes to diet-induced obesity by decreasing metabolism and energy expenditure, whereas TF-PAR2 signaling in hematopoietic and myeloid cells drives adipose tissue inflammation, hepatic steatosis, and insulin resistance. TF-initiated coagulation leading to thrombin-PAR1 signaling also contributes to diet-induced hepatic steatosis and inflammation in certain models. Thus, in obese patients, clinical markers of a prothrombotic state may indicate a risk for the development of complications of the metabolic syndrome. Furthermore, TF-induced signaling could provide new therapeutic targets for drug development at the intersection between obesity, inflammation, and thrombosis.

Indexed as

AdipocytesAdipose TissueAnimalsCardiovascular DiseasesGene Expression RegulationHumansInflammationInsulin ResistanceMacrophagesMetabolic SyndromeMiceMice, ObeseModels, BiologicalObesityPlasminogen Activator Inhibitor 1Receptor, PAR-1Plasminogen Activator Inhibitor 1Receptor, PAR-1Receptor, PAR-2SERPINE1 protein, humanThromboplastin

Identifiers

PMID24092932
PMCPMC3829115
OpenAlexW2054738316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.