ArticleMolecular biology and evolution2014
The characterization of sponge NLRs provides insight into the origin and evolution of this innate immune gene family in animals.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026Article
- NOD-Like Receptor Genes Undergo Diversity-Enhancing Evolution in a Fungal Species Complex.Genome biology and evolution · 2026Article
- Octameric dGTPase assemblies mediate broad anti-phage defense.Nature communications · 2026Article
- Article
- Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.The ISME journal · 2026Article
- NOD-like receptor repertoire in the chromosome-level genome of the demospongeFrontiers in immunology · 2026Article
- Nearly T2T, phased genome assemblies of corals reveal haplotype diversity and the evolutionary process of gene expansion.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi.PLoS genetics · 2025Article
- Reconstructing NOD-like receptor alleles with high internal conservation inMicrobial genomics · 2025Article
- The Chromosome-level Genome of the Ctenophore Mnemiopsis leidyi A. Agassiz, 1865 Reveals a Unique Immune Gene Repertoire.Genome biology and evolution · 2025Article
- Exploring the Innate Immunity in Invertebrates.Advances in experimental medicine and biology · 2025Review
- Challenges for the human immune system after leaving Earth.NPJ microgravity · 2024Review
- The Evolution of NLR Inflammasome and Its Mediated Pyroptosis in Metazoa.International journal of molecular sciences · 2024Article
- Transcriptomic responses of Mediterranean sponges upon encounter with symbiont microbial consortia.BMC genomics · 2024Article
- Copy number variation and population-specific immune genes in the model vertebrate zebrafish.eLife · 2024Article
- Evolution of the Major Components of Innate Immunity in Animals.Journal of molecular evolution · 2024Review
- Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin.International journal of molecular sciences · 2024Article
- Taking the lead: NLR immune receptor N-terminal domains execute plant immune responses.The New phytologist · 2023Review
- Body-Plan Reorganization in a Sponge Correlates with Microbiome Change.Molecular biology and evolution · 2023Article
- Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The "Nucleotide-binding domain and Leucine-rich Repeat" (NLR) genes are a family of intracellular pattern recognition receptors (PRR) that are a critical component of the metazoan innate immune system, involved in both defense against pathogenic microorganisms and in beneficial interactions with symbionts. To investigate the origin and evolution of the NLR gene family, we characterized the full NACHT domain-containing gene complement in the genome of the sponge, Amphimedon queenslandica. As sister group to all animals, sponges are ideally placed to inform our understanding of the early evolution of this ancient PRR family. Amphimedon queenslandica has a large NACHT domain-containing gene complement that is dominated by bona fide NLRs (n = 135) with varied phylogenetic histories. Approximately half of these have a tripartite architecture that includes an N-terminal CARD or DEATH domain. The multiplicity of the A. queenslandica NLR genes and the high variability across the N- and C-terminal domains are consistent with involvement in immunity. We also provide new insight into the evolution of NLRs in invertebrates through comparative genomic analysis of multiple metazoan and nonmetazoan taxa. Specifically, we demonstrate that the NLR gene family appears to be a metazoan innovation, characterized by two major gene lineages that may have originated with the last common eumetazoan ancestor. Subsequent lineage-specific gene duplication, gene loss and domain shuffling all have played an important role in the highly dynamic evolutionary history of invertebrate NLRs.
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