ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Biaxial deformation of collagen and elastin fibers in coronary adventitia.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.Journal of biomechanical engineering · 2025Article
- Investigating biochemical and structural changes of glycated collagen using multimodal multiphoton imaging, Raman spectroscopy, and atomic force microscopy.Analytical and bioanalytical chemistry · 2023Article
- SNR enhanced high-speed two-photon microscopy using a pulse picker and time gating detection.Scientific reports · 2023Article
- Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.Acta biomaterialia · 2022Article
- Biomechanics of human trabecular meshwork in healthy and glaucoma eyes via dynamic Schlemm's canal pressurization.Computer methods and programs in biomedicine · 2022Article
- Biophotonic tools for probing extracellular matrix mechanics.Matrix biology plus · 2021Article
- [Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- An Analytical Model for Estimating Alveolar Wall Elastic Moduli From Lung Tissue Uniaxial Stress-Strain Curves.Frontiers in physiology · 2020Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries.Nature communications · 2019Article
- Synchrotron-based visualization and segmentation of elastic lamellae in the mouse carotid artery during quasi-static pressure inflation.Journal of the Royal Society, Interface · 2019Article
- The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries.Applied bionics and biomechanics · 2019Article
- Micromechanics of elastic lamellae: unravelling the role of structural inhomogeneity in multi-scale arterial mechanics.Journal of the Royal Society, Interface · 2018Article
- Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy.Journal of visualized experiments : JoVE · 2018Article
- Chronic ETScientific reports · 2018Article
- Resuscitative endovascular balloon occlusion of the aorta: rupture risk and implications for blind inflation.Trauma surgery & acute care open · 2018Article
- Microstructure-based constitutive model of coronary artery with active smooth muscle contraction.Scientific reports · 2017Article
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- Re-examination of the mechanical anisotropy of porcine thoracic aorta by uniaxial tensile tests.Biomedical engineering online · 2016Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The microstructural deformation-mechanical loading relation of the blood vessel wall is essential for understanding the overall mechanical behavior of vascular tissue in health and disease. We employed simultaneous mechanical loading-imaging to quantify in situ deformation of individual collagen and elastin fibers on unstained fresh porcine coronary adventitia under a combination of vessel inflation and axial extension loading. Specifically, the specimens were imaged under biaxial loads to study microscopic deformation-loading behavior of fibers in conjunction with morphometric measurements at the zero-stress state. Collagen fibers largely orientate in the longitudinal direction, while elastin fibers have major orientation parallel to collagen, but with additional orientation angles in each sublayer of the adventitia. With an increase of biaxial load, collagen fibers were uniformly stretched to the loading direction, while elastin fibers gradually formed a network in sublayers, which strongly depended on the initial arrangement. The waviness of collagen decreased more rapidly at a circumferential stretch ratio of λθ = 1.0 than at λθ = 1.5, while most collagen became straightened at λθ = 1.8. These microscopic deformations imply that the longitudinally stiffer adventitia is a direct result of initial fiber alignment, and the overall mechanical behavior of the tissue is highly dependent on the corresponding microscopic deformation of fibers. The microstructural deformation-loading relation will serve as a foundation for micromechanical models of the vessel wall.
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