Evidence map›Paper›PMID 24092271›Full record

ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013

Molecular imaging in cardiovascular disease: Which methods, which diseases?

Jonathan R Lindner, Albert Sinusas

Abstract readReview
In one paragraph

Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Functional probes for cardiovascular molecular imaging.Quantitative imaging in medicine and surgery · 2018
    Review
  10. Molecular Imaging in Drug Discovery and Development.Circulation. Cardiovascular imaging · 2018
    Review
  11. Theranostics · 2018
    Article
  12. Article
  13. Review
  14. Measurement science in the circulatory system.Cellular and molecular bioengineering · 2014
    Article
  15. Pet Imaging and its Application in Cardiovascular Diseases.Methodist DeBakey cardiovascular journal
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jonathan R LindnerKnight Cardiovascular Institute, Oregon Health & Science University, UHN-62, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA, lindnerj@ohsu.edu.
Albert Sinusas
Oregon Health & Science University · USYale University · US

Funding

YR 50 PROJ- ROBERTS PRIMATE ISLETP51RR000163 · NCRR · OREGON REGIONAL PRIMATE RESEARCH CENTER · PI PICKER, LOUIS J. · 1985 to 2011
$140.8M
Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8M
Targeted CEU Imaging of Atherosclerosis and AngiogenesisR01HL078610 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2022
$6.8M
Molecular Imaging Predicts Atrial Remodeling and Fibrillation VulnerabilityR01HL113352 · NHLBI · YALE UNIVERSITY · PI AKAR, JOSEPH GABRIEL, SINUSAS, ALBERT J · 2013 to 2016
$2.8M
Contrast-enhanced Ultrasound Assessment of AngiogenesisR01HL074443 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2007
$1.5M
Molecular Imaging of Ischemic Memory with Ultrasound - Transition to HumansRC1HL100659 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LINDNER, JONATHAN R · 2009 to 2010
$979k
CCR NIH HHS RC01-100659NCRR NIH HHS P51 RR000163NHLBI NIH HHS P01 HL107205NHLBI NIH HHS P01-HL107205NHLBI NIH HHS R01 HL074443NHLBI NIH HHS R01 HL078610NHLBI NIH HHS R01-HL078610NHLBI NIH HHS R01 HL113352NHLBI NIH HHS R01-HL113352NHLBI NIH HHS RC1 HL100659
6 · The paper itself

Abstract

Techniques for in vivo assessment of disease-related molecular changes are being developed for all forms of non-invasive cardiovascular imaging. The ability to evaluate tissue molecular or cellular phenotype in patients has the potential to not only improve diagnostic capabilities but to enhance clinical care either by detecting disease at an earlier stage when it is more amenable to therapy, or by guiding most appropriate therapies. These new techniques also can be used in research programs in order to characterize pathophysiology and as a surrogate endpoint for therapeutic efficacy. The most common approach for molecular imaging involves the creation of novel-targeted contrast agents that are designed so that their kinetic properties are different in disease tissues. The main focus of this review is not to describe all the different molecular imaging approaches that have been developed, but rather to describe the status of the field and highlight some of the clinical and research applications that molecular imaging will likely provide meaningful benefit. Specific target areas include assessment of atherosclerotic disease, tissue ischemia, and ventricular and vascular remodeling.

Indexed as

Molecular ImagingCardiovascular DiseasesHumansMyocardial IschemiaNeovascularization, PhysiologicRegenerationVentricular Remodeling

Identifiers

PMID24092271
PMCPMC3943209
OpenAlexW2107820964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.