ReviewJournal of mammary gland biology and neoplasia2013
Deconvoluting the obesity and breast cancer link: secretome, soil and seed interactions.
Review in Journal of mammary gland biology and neoplasia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Racial and ethnic variation in body composition and prognosis of nonmetastatic breast cancer.Cancer · 2025Article
- Modifiers of radiation effects on breast cancer incidence revealed by a reanalysis of archival data of rat experiments.Journal of radiation research · 2023Article
- Mechanistic Targets and Nutritionally Relevant Intervention Strategies to Break Obesity-Breast Cancer Links.Frontiers in endocrinology · 2021Review
- Changes in DNA Methylation and Gene Expression of Insulin and Obesity-Related GeneInternational journal of molecular sciences · 2020Article
- Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages.Biomolecules · 2020Article
- Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts.Scientific reports · 2018Article
- TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Dietary regulation of allometric ductal growth in the mammary glands.Journal of animal science · 2017Review
- Associations of the Transforming Growth Factor β/Smad Pathway, Body Mass Index, and Physical Activity With Breast Cancer Outcomes: Results From the Shanghai Breast Cancer Study.American journal of epidemiology · 2016Article
- Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells.Frontiers in endocrinology · 2016Review
- Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients.BMC obesity · 2016Article
- cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer.SpringerPlus · 2016Article
- Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche.Neoplasia (New York, N.Y.) · 2015Article
- Targeting the COX-2 Pathway to Improve Therapeutic Response in the Obese Breast Cancer Patient Population.Current pharmacology reports · 2015Article
- A Review: Proteomics in Nasopharyngeal Carcinoma.International journal of molecular sciences · 2015Review
- Obesity and cancer pathogenesis.Annals of the New York Academy of Sciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity is associated with increased risk of breast cancer in postmenopausal women and is linked with poor prognosis in pre- and postmenopausal breast cancer patients. The mechanisms underlying the obesity-breast cancer connection are becoming increasingly clear and provide multiple opportunities for primary to tertiary prevention. Several obesity-related host factors can influence breast tumor initiation, progression and/or response to therapy, and these have been implicated as key contributors to the complex effects of obesity on cancer incidence and outcomes. These host factors include components of the secretome, including insulin, insulin-like growth factor-1, leptin, adiponectin, steroid hormones, cytokines, vascular regulators, and inflammation-related molecules, as well as the cellular and structural components of the tumor microenvironment. These secreted and structural host factors are extrinsic to, and interact with, the intrinsic molecular characteristics of breast cancer cells (including breast cancer stem cells), and each will be considered in the context of energy balance and as potential targets for cancer prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.