ReviewCellular and molecular life sciences : CMLS2014
Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Research trends and hotspots on global influenza and inflammatory response based on bibliometrics.Virology journal · 2024Review
- Regulatory role of microRNAs in virus-mediated inflammation.Journal of inflammation (London, England) · 2024Review
- The Association between Influenza Vaccine and Risk of Chronic Kidney Disease/Dialysis in Patients with Hypertension.Vaccines · 2023Article
- Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections.Microbial biotechnology · 2023Article
- Article
- The influenza virus RNA polymerase as an innate immune agonist and antagonist.Cellular and molecular life sciences : CMLS · 2021Review
- The Roles of Neutrophils in Cytokine Storms.Viruses · 2021Review
- The Anti-Viral and Anti-Inflammatory Properties of Edible Bird's Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical Application.Frontiers in pharmacology · 2021Review
- Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection.Frontiers in immunology · 2021Article
- Viral-Host Interactome Analysis Reveals Chicken STAU2 Interacts With Non-structural Protein 1 and Promotes the Replication of H5N1 Avian Influenza Virus.Frontiers in immunology · 2021Article
- The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus.International journal of molecular sciences · 2018Article
- Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host.Current opinion in virology · 2018Review
- Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian models.Virulence · 2018Article
- Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.British journal of pharmacology · 2018Article
- The inflammatory response triggered by Influenza virus: a two edged sword.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells.Frontiers in microbiology · 2017Article
- FPR2: A Novel Promising Target for the Treatment of Influenza.Frontiers in microbiology · 2017Review
- Involvement of the different lung compartments in the pathogenesis of pH1N1 influenza virus infection in ferrets.Veterinary research · 2016Article
- Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice.Antiviral chemistry & chemotherapy · 2015Article
- Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.