ArticleVeterinary pathology2014
Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo.
Article in Veterinary pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mouse Models of Breast Cancer Bone Metastasis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- The progressive trend of modeling and drug screening systems of breast cancer bone metastasis.Journal of biological engineering · 2024Review
- Voluntary wheel running reduces tumor growth and increases capillarity in the heart during doxorubicin chemotherapy in a murine model of breast cancer.Frontiers in physiology · 2024Article
- Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer.Oncology reports · 2023Article
- Tumor vessel co-option: The past & the future.Frontiers in oncology · 2022Review
- Optimization of a syngeneic murine model of bone metastasis.Journal of bone oncology · 2020Article
- TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases.Cancers · 2020Article
- Chemokine releasing particle implants for trapping circulating prostate cancer cells.Scientific reports · 2020Article
- Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons.Molecular therapy. Nucleic acids · 2020Article
- Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging.Oncology reports · 2019Article
- Immunomodulatory role of histamine H4 receptor in breast cancer.British journal of cancer · 2019Article
- Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry.Scientific reports · 2018Article
- IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.Nature cell biology · 2018Article
- Feline Mammary Cancer.Veterinary pathology · 2017Article
- Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin.PloS one · 2017Article
- A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer.Journal of visualized experiments : JoVE · 2016Article
- Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis.Journal of visualized experiments : JoVE · 2016Article
- Murine models of breast cancer bone metastasis.BoneKEy reports · 2016Article
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Authors and funding
7 authors.
Funding
Abstract
Metastasis is the primary cause of death in breast cancer patients, yet there are challenges to modeling this process in vivo. The goal of this study was to analyze the effects of injection site on tumor growth and metastasis and gene expression of breast cancer cells in vivo using the MMTV-PymT breast cancer model (Met-1 cells). Met-1 cells were injected into 5 sites (subcutaneous, mammary fat pad, tail vein, intracardiac, and intratibial), and tumors and metastases were monitored using bioluminescent imaging and confirmed with gross necropsy and histopathology. Met-1 tumors were analyzed based on morphology and changes in gene expression in each tissue microenvironment. There were 6 permissible sites of Met-1 tumor growth (mammary gland, subcutis, lung, adrenal gland, ovary, bone). Met-1 cells grew faster in the subcutis compared to mammary fat pad tumors (highest Ki-67 index). Morphologic differences were evident in each tumor microenvironment. Finally, 7 genes were differentially expressed in the Met-1 tumors in the 6 sites of growth or metastasis. This investigation demonstrates that breast cancer progression and metastasis are regulated by not only the tumor cells but also the experimental model and unique molecular signals from the tumor microenvironment.
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