ArticleScientific reports2013
Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic β-cells.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Principles for the design of multicellular engineered living systems.APL bioengineering · 2022Article
- Engineering and Characterization of a Biomimetic Microchip for Differentiating Mouse Adipocytes in a 3D Microenvironment.Pharmaceutical research · 2022Article
- In Vitro Disease Models of the Endocrine Pancreas.Biomedicines · 2021Review
- Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments.Advanced functional materials · 2020Article
- Bio-orthogonal, Site-Selective Conjugation of Recombinant Proteins to Microporous Annealed Particle Hydrogels for Tissue Engineering.Advanced therapeutics · 2020Article
- Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments.Scientific reports · 2019Article
- Microfluidic preparation, shrinkage, and surface modification of monodispersed alginate microbeads for 3D cell culture.RSC advances · 2019Article
- Nanotechnology in cell replacement therapies for type 1 diabetes.Advanced drug delivery reviews · 2019Review
- Hydrogel microenvironments for cancer spheroid growth and drug screening.Science advances · 2018Review
- 3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets.Stem cell reviews and reports · 2018Review
- Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model.BJU international · 2018Article
- Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.PloS one · 2018Article
- Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.Journal of materials science. Materials in medicine · 2017Article
- Clickable Microgel Scaffolds as Platforms for 3D Cell Encapsulation.Advanced healthcare materials · 2017Article
- Tissue Engineering Approaches in the Design of Healthy and PathologicalFrontiers in bioengineering and biotechnology · 2017Review
- Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function.Nanoscale · 2016Article
- Two-dimensional arrays of cell-laden polymer hydrogel modules.Biomicrofluidics · 2016Article
- Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells.Pflugers Archiv : European journal of physiology · 2015Article
- Engineering biomimetic materials for islet transplantation.Current diabetes reviews · 2015Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular matrix (ECM) interactions as β-cells lose their native microenvironment. Herein, we built an ex-vivo cell microenvironment by culturing primary β-cells in direct contact with 'synthetic neighbors', cell-sized soft polymer microbeads that were modified with cell-cell signaling factors as well as components from pancreatic-tissue-specific ECMs. This biomimetic 3D microenvironment was able to promote native cell-cell and cell-ECM interactions. We obtained sustained maintenance of β-cell function in vitro enhanced cell viability from the few days usually observed in 2D culture to periods exceeding three weeks, with enhanced β-cell stability and insulin production. Our approach can be extended to create a general 3D culture platform for other cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.