ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2014
Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The diabetic neuropathy and bone mineral density in type 2 diabetes mellitus: a cross-sectional and meta-analytic study.Clinical and experimental medicine · 2025Pooled it
- Therapeutics of Charcot neuroarthropathy and pharmacological mechanisms: A bone metabolism perspective.Frontiers in pharmacology · 2023Review
- The protective effects of long non-coding RNA-ANCR on arterial calcification.Journal of bone and mineral metabolism · 2020Article
- The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications.International journal of molecular sciences · 2019Review
- Vascular disease in the lower limb in type 1 diabetes.Cardiovascular endocrinology & metabolism · 2019Review
- Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics.Scientific reports · 2019Article
- Musculoskeletal problems in diabetes mellitus.European journal of rheumatology · 2018Review
- Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy.Journal of diabetes investigation · 2018Article
- Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling.Journal of nutrition and metabolism · 2018Review
- Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot.Journal of diabetes research · 2018Article
- Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy.Journal of orthopaedic surgery and research · 2017Review
- Prevalence of polymorphisms in OPG, RANKL and RANK as potential markers for Charcot arthropathy development.Scientific reports · 2017Article
- The Charcot foot as a complication of diabetic neuropathy.Current diabetes reports · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Emerging evidence from the last two decades has shown that vascular calcification (VC) is a regulated, cell-mediated process orchestrated by vascular smooth muscle cells (VSMCs) and that this process bears many similarities to bone mineralization. While many of the mechanisms driving VSMC calcification have been well established, it remains unclear what factors in specific disease states act to promote vascular calcification and in parallel, bone loss. Diabetes is a condition most commonly associated with VC and bone abnormalities. In this review, we describe how factors associated with the diabetic milieu impact on VSMCs, focusing on the role of oxidative stress, inflammation, impairment of the advanced glycation end product (AGE)/receptor for AGE system and, importantly, diabetic neuropathy. We also explore the link between bone and VC in diabetes with a specific emphasis on the receptor activator of nuclear factor κβ ligand/osteoprotegerin system. Finally, we describe what insights can be gleaned from studying Charcot osteoarthropathy, a rare complication of diabetic neuropathy, in which the occurrence of VC is frequent and where bone lysis is extreme.
Indexed as
Identifiers
24091593What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.