Trial reportChest2014
A validated risk model to predict 90-day VTE events in postsurgical patients.
Trial report in Chest, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.Health technology assessment (Winchester, England) · 2024Pooled it
- Simultaneous versus staged bilateral total hip arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Risk assessment models for venous thromboembolism in hospitalised adult patients: a systematic review.BMJ open · 2021Pooled it
- Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology.Systematic reviews · 2014Pooled it
- Review
- A multicenter retrospective study on the risk factors of stricture formation after moderate circumferential defect resection in esophageal endoscopic submucosal dissection.Surgical endoscopy · 2026Observational
- Optimizing venous thromboembolism chemoprophylaxis in abdominal-based breast reconstruction: a narrative review of evidence and practice.Gland surgery · 2025Review
- The CLUE postsurgery VTE risk instrument for abdominal and pelvic surgery: validation of patient risk factor component.Blood advances · 2025Article
- Racial disparities in extended venous thromboembolism prophylaxis after hysterectomy.PloS one · 2025Article
- A composite risk assessment model for venous thromboembolism.Journal of vascular surgery. Venous and lymphatic disorders · 2025Article
- Venous thromboembolism prophylaxis usage among surgical patients in both private and public hospitals in Ethiopia.Heliyon · 2024Article
- The Benefits and Imperative of Venous Thromboembolism Risk Screening for Hospitalized Patients: A Systematic Review.Journal of clinical medicine · 2023Review
- Can Risk-Based Thromboprophylaxis Practice Guidelines be Safely Used in Esophagectomy Cases? Experience of an Academic Health System.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Venous thromboembolism (VTE) prophylaxis after bariatric surgery: a national survey of MBSAQIP director practices.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
- The Safety and Efficacy of Apixaban (Eliquis) in 5017 Post-bariatric Patients with 95.3% Follow-up: a Multicenter Study.Obesity surgery · 2022Article
- Extended-duration thromboprophylaxis after ventral hernia repair: a risk model to predict venous thrombotic events after hospital discharge.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Factors Affecting the Decision to Initiate Anticoagulation After Spine Surgery: Findings From the AOSpine Anticoagulation Global Initiative.Global spine journal · 2022Article
- A retrospective analysis based on multiple machine learning models to predict lymph node metastasis in early gastric cancer.Frontiers in oncology · 2022Article
- Systematic reviews of observational studies of Risk of Thrombosis and Bleeding in General and Gynecologic Surgery (ROTBIGGS): introduction and methodology.Systematic reviews · 2021Review
- Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis.Journal of thrombosis and haemostasis : JTH · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundVTE is the proximate cause of 100,000 deaths in the United States each year. Perioperative VTE risk among surgical patients varies by 20-fold, which highlights the importance of risk stratification to identify high-risk patients, in whom chemoprophylaxis can decrease VTE risk, and low-risk patients, for whom the risk-benefit relationship of prophylaxis may be unfavorable.
methodsWe used data from a statewide surgical quality collaborative for surgical procedures performed between 2010 and 2012. Regression-based techniques identified predictors of 90-day VTE while adjusting for procedural complexity and comorbid conditions. A weighted risk index was created and was validated subsequently in a separate, independent dataset.
resultsData were available for 10,344 patients, who were allocated randomly to a derivation or validation cohort. The 90-day VTE rate was 1.4%; 66.2% of the derivation cohort and 65.5% of the validation cohort received chemoprophylaxis. Seven risk factors were incorporated into a weighted risk index: personal history of VTE, current cancer, sepsis/septic shock/systemic inflammatory response syndrome, age≥60 years, BMI≥40 kg/m2, male sex, and family history of VTE. Prediction for 90-day VTE was similar in the derivation and validation cohorts (areas under the receiver operator curve, 0.72 and 0.70, respectively). An 18-fold variation in 90-day VTE rate was identified.
conclusionsA weighted risk index quantifies 90-day VTE risk among surgical patients and identifies an 18-fold variation in VTE risk among the overall surgical population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.