Evidence map›Paper›PMID 24090975›Full record

ArticleBiochemical and biophysical research communications2013

Developmental cis-regulatory analysis of the cyclin D gene in the sea urchin Strongylocentrotus purpuratus.

Christopher M McCarty, James A Coffman

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals.Developmental dynamics : an official publication of the American Association of Anatomists · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Christopher M McCartyMount Desert Island Biological Laboratory, PO Box 35, Salisbury Cove, ME 04672, USA; The Graduate School of Biomedical Science and Engineering, The University of Maine, Orono, ME 04469, USA. Electronic address: cmccarty@mdibl.org.
James A Coffman
Mount Desert Island Biological Laboratory · USThe Graduate Center, CUNY · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Control of Cell Proliferation by Runx ProteinsR01GM070840 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI COFFMAN, JAMES A · 2005 to 2009
$1.4M
NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20-GM103423NIGMS NIH HHS R01 GM070840NIGMS NIH HHS R01-GM070840
6 · The paper itself

Abstract

Cyclin D genes regulate the cell cycle, growth and differentiation in response to intercellular signaling. While the promoters of vertebrate cyclin D genes have been analyzed, the cis-regulatory sequences across an entire cyclin D locus have not. Doing so would increase understanding of how cyclin D genes respond to the regulatory states established by developmental gene regulatory networks, linking cell cycle and growth control to the ontogenetic program. Therefore, we conducted a cis-regulatory analysis on the cyclin D gene, SpcycD, of the sea urchin, Strongylocentrotus purpuratus, during embryogenesis, identifying upstream and intronic sequences, located within six defined regions bearing one or more cis-regulatory modules each.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCyclin DEmbryo, NonmammalianGene Regulatory NetworksPromoter Regions, GeneticStrongylocentrotus purpuratusCyclin D5′ untranslated region5′ UTRcis-Regulatory analysiscis-regulatory moduleCRMCyclin DDevelopmentgene regulatory networkGRNhours post-fertilizationhpfSea urchin embryoStrongylocentrotus purpuratus

Identifiers

PMID24090975
PMCPMC3871186
OpenAlexW2010314824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.