ArticleParkinsonism & related disorders2014
Dopaminergic modulation of motor coordinaton in Parkinson's disease.
Article in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- A methodological scoping review on EMG processing and synergy-based results in muscle synergy studies in Parkinson's disease.Frontiers in bioengineering and biotechnology · 2024Pooled it
- Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parkinson's disease.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2017Trial
- Finger force changes in the absence of visual feedback in patients with Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Trial
- Same geometry, different dynamics: what uncontrolled manifold (UCM) analysis misses about motor control.Experimental brain research · 2026Article
- Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.Experimental brain research · 2026Article
- Functional changes in spinal circuitry in essential tremor revealed with analysis of intramuscle synergies.Journal of neurophysiology · 2026Article
- Altered regularity and stability of multi-finger force production in individuals with mild cognitive impairment.Frontiers in human neuroscience · 2026Article
- Carpal tunnel release surgery restores force control but not force coordination in CTS patients.Scientific reports · 2025Article
- Bimanual coordination and neuromuscular synchronization in Parkinson's disease and healthy adults.Experimental brain research · 2025Article
- Two aspects of feed-forward control of action stability: effects of action speed and unexpected events.Experimental brain research · 2024Article
- The effect of dopaminergic treatment on whole body kinematics explored through network theory.Scientific reports · 2024Article
- Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.Neurotoxicology · 2022Article
- Recent Advances in the Neural Control of Movements: Lessons for Functional Recovery.Physical therapy research · 2022Review
- One more time about motor (and non-motor) synergies.Experimental brain research · 2021Review
- Stability of Action and Kinesthetic Perception in Parkinson's Disease.Journal of human kinetics · 2021Article
- Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergies stabilizing vertical posture.Experimental brain research · 2020Article
- Synergic control of action in levodopa-naïve Parkinson's disease patients: I. Multi-finger interaction and coordination.Experimental brain research · 2020Article
- Postural Behavior in Medicated Parkinson Disease Patients: A Preliminary Study Searching for Indicators to Track Progress.Journal of central nervous system disease · 2020Article
- Preparation to a quick whole-body action: control with referent body orientation and multi-muscle synergies.Experimental brain research · 2019Article
- Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe applied the idea of synergies and the framework of the uncontrolled manifold hypothesis to explore the effects of dopamine replacement therapy on finger interaction and coordination in patients with early-stage Parkinson's disease (PD).
methodsEight patients performed single-finger and multi-finger force production tasks with both the dominant and non-dominant hand before (off-drug) and after (on-drug) taking their dopaminergic medications. Synergy indices were defined as co-varied adjustments of commands to fingers that stabilized the total force produced by the hand.
resultsPD patients showed significantly lower maximal finger forces off-drug compared to the on-drug condition, while indices of finger individuation (enslaving) were unchanged. The synergy indices were weaker during steady-state force production off-drug compared to on-drug. Anticipatory adjustments of synergies prior to the quick force pulse initiation were delayed and reduced off-drug as compared to the on-drug condition. These drug effects were observed in both the symptomatic and asymptomatic hands of the patients whose symptoms were limited to one side of the body.
conclusionsThe study demonstrates dopaminergic modulation of motor coordination in PD and supports that the analysis of different components of multi-finger synergies offers a set of indices sensitive to the effects of dopamine replacement therapy in early-stage PD. The results suggest an important role of the basal ganglia in synergy formation and in feed-forward synergy adjustments. Future studies using these methods may yield more objective, quantitative biomarker(s) of motor coordination impairments in PD, and better understanding of subcortical involvement in the neural control of natural actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.