ArticleThe journal of spinal cord medicine2014
Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats.
Article in The journal of spinal cord medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Therapeutic Effects of Noninvasive Technology Modalities on Lower-Limb Motor Function in Spinal Cord Injury: A Systematic Review.Archives of rehabilitation research and clinical translation · 2025Review
- Activation of nociception-sensitive ionotropic glutamate receptor-expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats.FASEB bioAdvances · 2024Article
- Manipulating facial musculature with functional electrical stimulation as an intervention for major depressive disorder: a focused search of literature for a proposal.Journal of neuroengineering and rehabilitation · 2023Review
- Functional electrical stimulation therapy for upper extremity rehabilitation following spinal cord injury: a pilot study.Spinal cord series and cases · 2023Article
- Pain inhibition-the unintended benefit of electrically elicited muscle strengthening contractions.BMC musculoskeletal disorders · 2023Article
- BCI system with lower-limb robot improves rehabilitation in spinal cord injury patients through short-term training: a pilot study.Cognitive neurodynamics · 2022Article
- The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Review
- Review
- Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of Functional Electrical Stimulation Cycling of Different Duration on Viscoelastic and Electromyographic Properties of the Knee in Patients with Spinal Cord Injury.Brain sciences · 2020Article
- (-)-Epicatechin reduces muscle waste after complete spinal cord transection in a murine model: role of ubiquitin-proteasome system.Molecular biology reports · 2020Article
- Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats.Neuroscience bulletin · 2020Article
- Intermittent Fasting After Spinal Cord Injury Does Not Improve the Recovery of Baroreflex Regulation in the Rat.Frontiers in physiology · 2020Article
- Functional electrical stimulation of the facial muscles to improve symptoms in individuals with major depressive disorder: pilot feasibility study.Biomedical engineering online · 2019Article
- Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia.Scientific reports · 2019Article
- Current Change Rate Influences Sensorimotor Cortical Excitability During Neuromuscular Electrical Stimulation.Frontiers in human neuroscience · 2019Article
- Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract.American journal of physiology. Heart and circulatory physiology · 2017Article
- Platelet rich plasma: Effective treatment for repairing of spinal cord injury in rat.Acta orthopaedica et traumatologica turcica · 2017Article
- Restoration of Hindlimb Movements after Complete Spinal Cord Injury Using Brain-Controlled Functional Electrical Stimulation.Frontiers in neuroscience · 2017Article
- Restoring voluntary grasping function in individuals with incomplete chronic spinal cord injury: pilot study.Topics in spinal cord injury rehabilitation · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
backgroundFunctional electrical stimulation (FES) has been found to be effective in restoring voluntary functions after spinal cord injury (SCI) and stroke. However, the central nervous system (CNS) changes that occur in as a result of this therapy are largely unknown.
objectiveTo examine the effects of FES on the restoration of voluntary locomotor function of the CNS in a SCI rat model.
methodsSCI rats were instrumented with chronic FES electrodes in the hindlimb muscles and were divided into two groups: (a) FES therapy and (b) sedentary. At day 7 post-SCI, the animals were assessed for locomotion performance by using a Basso, Beattie and Bresnahan (BBB) scale. They were then anesthetized for a terminal in vivo experiment. The lumbar spinal cord and somatosensory cortex were exposed and the instrumented muscles were stimulated electrically. Associated neurovascular responses in the CNS were recorded with an intrinsic optical imaging system.
resultsFES greatly improved locomotion recovery by day 7 post-SCI, as measured by BBB scores (P < 0.05): (a) FES 10 ± 2 and (b) controls 3 ± 1. Furthermore, the FES group showed a significant increase (P < 0.05) of neurovascular activation in the spinal cord and somatosensory cortex when the muscles were stimulated between 1 and 3 motor threshold (MT).
conclusionHind limb rehabilitation with FES is an effective strategy to improve locomotion during the acute phase post-SCI. The results of this study indicate that after FES, the CNS preserves/acquires the capacity to respond to peripheral electrical stimulation.
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