ArticleReproductive toxicology (Elmsford, N.Y.)2014
Prepubertal exposure to arsenic(III) suppresses circulating insulin-like growth factor-1 (IGF-1) delaying sexual maturation in female rats.
Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cadmium exposure during adolescence and young adulthood induces signatures of metabolic dysfunction-associated steatotic liver disease.Scientific reports · 2025Article
- Article
- Manganese-induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation in Female Rats.Endocrinology · 2025Article
- Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother-Child Cohort Study in Bangladesh.Environmental health perspectives · 2023Article
- Invited Perspective: Metals and Menarche.Environmental health perspectives · 2023Article
- The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.Reproductive biology and endocrinology : RB&E · 2022Article
- Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures.Brain sciences · 2019Article
- In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City.Environmental research · 2019Article
- Embryonic arsenic exposure reduces intestinal cell proliferation and alters hepatic IGF mRNA expression in killifish (Fundulus heteroclitus).Journal of toxicology and environmental health. Part A · 2019Article
- Embryonic-only arsenic exposure in killifish (Fundulus heteroclitus) reduces growth and alters muscle IGF levels one year later.Aquatic toxicology (Amsterdam, Netherlands) · 2017Article
- Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease.Journal of biochemical and molecular toxicology · 2016Article
- Comment on "Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice".Environmental health perspectives · 2016Article
- Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice.Environmental health perspectives · 2016Article
- Effects of Arsenite Exposure during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Disease in Male Mice.Environmental health perspectives · 2016Article
- Article
- Application of Sholl analysis to quantify changes in growth and development in rat mammary gland whole mounts.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Alteration of mammary gland development and gene expression by in utero exposure to arsenic.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats.Experimental biology and medicine (Maywood, N.J.) · 2014Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Arsenic (As) is a prevalent environmental toxin readily accessible for human consumption and has been identified as an endocrine disruptor. However, it is not known what impact As has on female sexual maturation. Therefore, in the present study, we investigated the effects of prepubertal exposure on mammary gland development and pubertal onset in female rats. Results showed that prepubertal exposure to 10 mg/kg of arsenite (As(III)) delayed vaginal opening (VO) and prepubertal mammary gland maturation. We determined that As accumulates in the liver, disrupts hepatocyte function and suppresses serum levels of the puberty related hormone insulin-like growth factor 1 (IGF-1) in prepubertal animals. Overall, this is the first study to show that prepubertal exposure to As(III) acts peripherally to suppress circulating levels of IGF-1 resulting in delayed sexual maturation. Furthermore, this study identifies a critical window of increased susceptibility to As(III) that may have a lasting impact on female reproductive function.
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