ArticlePsychiatry research2013
Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study.
Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cerebral glucose metabolism in bipolar disorder: A voxel-based meta-analysis of positron emission tomography studies.Brain and behavior · 2021Pooled it
- Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.Molecular psychiatry · 2018Pooled it
- Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.Journal of psychopathology and clinical science · 2024Article
- Alterations of brainstem volume in patients with first-episode and recurrent major depressive disorder.BMC psychiatry · 2023Article
- Cerebellar Activation Deficits in Schizophrenia During an Eyeblink Conditioning Task.Schizophrenia bulletin open · 2021Article
- Investigating cerebellar neural function in schizophrenia using delay eyeblink conditioning: A pilot fMRI study.Psychiatry research. Neuroimaging · 2020Article
- Polarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.Cerebellum (London, England) · 2020Article
- Prediction, Psychosis, and the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Hippocampal Non-Theta-Contingent Eyeblink Classical Conditioning: A Model System for Neurobiological Dysfunction.Frontiers in psychiatry · 2016Review
- New Insights into the Nature of Cerebellar-Dependent Eyeblink Conditioning Deficits in Schizophrenia: A Hierarchical Linear Modeling Approach.Frontiers in psychiatry · 2016Article
- Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases.Frontiers in psychiatry · 2015Review
- Timing Tasks Synchronize Cerebellar and Frontal Ramping Activity and Theta Oscillations: Implications for Cerebellar Stimulation in Diseases of Impaired Cognition.Frontiers in psychiatry · 2015Review
- Eyeblink Conditioning in Schizophrenia: A Critical Review.Frontiers in psychiatry · 2015Review
- Cerebellar-motor dysfunction in schizophrenia and psychosis-risk: the importance of regional cerebellar analysis approaches.Frontiers in psychiatry · 2014Review
- The therapeutic potential of the cerebellum in schizophrenia.Frontiers in systems neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Previous studies suggest that patients with schizophrenia exhibit dysfunctions in a widely distributed circuit-the cortico-cerebellar-thalamic-cortical circuit, or CCTCC-and that this may explain the multiple cognitive deficits observed in the disorder. This study uses positron emission tomography (PET) with O(15) H₂O to measure regional cerebral blood flow (rCBF) in response to a classic test of cerebellar function, the associative learning that occurs during eyeblink conditioning, in a sample of 20 unmedicated schizophrenia patients and 20 closely matched healthy controls. The PET paradigm examined three phases of acquisition and extinction (early, middle and late). The patients displayed impaired behavioral performance during both acquisition and extinction. The imaging data indicate that, compared to the control subjects, the patients displayed decreases in rCBF in all three components of the CCTCC during both acquisition and extinction. Specifically, patients had less rCBF in the middle and medial frontal lobes, anterior cerebellar lobules I/V and VI, as well as the thalamus during acquisition and although similar areas were found in the frontal lobe, ipsilateral cerebellar lobule IX showed consistently less activity in patients during extinction. Thus this study provides additional support for the hypothesis that patients with schizophrenia have a cognitive dysmetria--an inability to smoothly coordinate many different types of mental activity--that affects even a very basic cognitive task that taps into associative learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.