ArticleBioMed research international2013
Identifying cell class specific losses from serially generated electroretinogram components.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Technical note: contour plot visualization of the light adapted electroretinogram using a generalized additive model.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson's disease.Frontiers in neuroscience · 2023Article
- The Effect of Aging on Retinal Function and Retinal Ganglion Cell Morphology Following Intraocular Pressure Elevation.Frontiers in aging neuroscience · 2022Article
- Electroretinography and contrast sensitivity, complementary translational biomarkers of sensory deficits in the visual system of individuals with fragile X syndrome.Journal of neurodevelopmental disorders · 2021Article
- Loss of Caveolin-1 Impairs Light Flicker-Induced Neurovascular Coupling at the Optic Nerve Head.Frontiers in neuroscience · 2021Article
- Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina.Frontiers in neuroscience · 2020Article
- Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model.Scientific reports · 2018Article
- Functional Analysis and Immunochemical Analyses of CaExperimental neurobiology · 2018Article
- Full-field electroretinogram in autism spectrum disorder.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- Deficient glucose and glutamine metabolism inMolecular vision · 2016Article
- Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.PloS one · 2014Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeProcessing of information through the cellular layers of the retina occurs in a serial manner. In the electroretinogram (ERG), this complicates interpretation of inner retinal changes as dysfunction may arise from "upstream" neurons or may indicate a direct loss to that neural generator. We propose an approach that addresses this issue by defining ERG gain relationships.
methodsRegression analyses between two serial ERG parameters in a control cohort of rats are used to define gain relationships. These gains are then applied to two models of retinal disease.
resultsThe PIII(amp) to PII(amp) gain is unity whereas the PII(amp) to pSTR(amp) and PII(amp) to nSTR(amp) gains are greater than unity, indicating "amplification" (P < 0.05). Timing relationships show amplification between PIII(it) to PII(it) and compression for PII(it) to pSTR(it) and PII(it) to nSTR(it), (P < 0.05). Application of these gains to ω-3-deficiency indicates that all timing changes are downstream of photoreceptor changes, but a direct pSTR amplitude loss occurs (P < 0.05). Application to diabetes indicates widespread inner retinal dysfunction which cannot be attributed to outer retinal changes (P < 0.05).
conclusionsThis simple approach aids in the interpretation of inner retinal ERG changes by taking into account gain characteristics found between successive ERG components of normal animals.
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