ArticleBioMed research international2013
A biosurfactant-sophorolipid acts in synergy with antibiotics to enhance their efficiency.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Biosurfactants as Antibiofilm Agents for Medical Devices: Mechanisms, Evidence and Integration into Infection Prevention and Control.Microorganisms · 2026Review
- Overcoming Candida albicans biofilm drug resistance via azole-sophorolipid synergy.Scientific reports · 2026Article
- A Glycolipid-Like Biosurfactant Molecule Derived From anInternational journal of microbiology · 2026Article
- Sophorolipid-Based Biosurfactant Application for Carbonated Water Flooding: An Experimental Approach for Enhanced Oil Recovery.ACS omega · 2025Article
- Lactonic sophorolipids byRSC advances · 2025Article
- Novel Animal Model of Enterobacteria Pathogenicity, Virulence, and Amoxicillin-Biosurfactant Synergic Using Nsombé (Rhynchophorus phoenicis Larvae).MicrobiologyOpen · 2025Article
- Antioxidant Properties of Biosurfactants: Multifunctional Biomolecules with Added Value in Formulation Chemistry.Biomolecules · 2025Review
- Going to extremes: progress in exploring new environments for novel antibiotics.npj antimicrobials and resistance · 2024Review
- Study on the production of Sophorolipid by Starmerella bombicola yeast using fried waste oil fermentation.Bioscience reports · 2024Article
- War and peace: exploring microbial defence systems as a source of new antimicrobial therapies.Frontiers in pharmacology · 2024Review
- Article
- Glycolipid Biosurfactants in Skincare Applications: Challenges and Recommendations for Future Exploitation.Molecules (Basel, Switzerland) · 2023Review
- Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin.Chemical science · 2022Article
- Article
- Sophorolipids-Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health.Molecules (Basel, Switzerland) · 2022Review
- Comparison of inhibitory effects and mechanisms of lactonic sophorolipid on different pathogenic bacteria.Frontiers in microbiology · 2022Article
- Low-cost production and application of lipopeptide for bioremediation and plant growth by Bacillus subtilis SNW3.AMB Express · 2021Article
- Antimicrobial effects of sophorolipid in combination with lactic acid against poultry-relevant isolates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants.Pharmaceutics · 2021Review
- Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review.Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sophorolipids (SLs), biosurfactants with antimicrobial properties, have been tried to address the problem of antibiotic resistance. The synergistic action of SL and antibiotics was checked using standard microdilution and spread plate methods. With Staphylococcus aureus, SL-tetracycline combination achieved total inhibition before 4 h of exposure while tetracycline alone couldnot achieve total inhibition till the end of 6 h. The inhibition caused by exposure of bacterium to SL-tetracycline mixture was ~25% more as compared to SL alone. In spite of known robustness of gram-negative bacteria, SL-cefaclor mixture proved to be efficient against Escherichia coli which showed ~48% more inhibition within 2 h of exposure as compared to cefaclor alone. Scanning electron microscopy of the cells treated with mixture revealed bacterial cell membrane damage and pore formation. Moreover, SLs being a type of asymmetric bola, they are expected to form self-assemblies with unique functionality. This led to the speculation that SLs being amphiphilic in nature can span through the structurally alike cell membrane and facilitate the entry of drug molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.