ArticleDiabetes care2013
Short leg length, a marker of early childhood deprivation, is associated with metabolic disorders underlying type 2 diabetes: the PROMISE cohort study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The association between adult height and the incidence of diabetes in a Japanese working population: a prospective study exploring the possible role of cohort effects.BMC public health · 2026Article
- Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.International journal of environmental research and public health · 2026Article
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
- Independent association of leg-height ratio with 15 cardiometabolic diseases.Cardiovascular diabetology · 2026Article
- Humero-femoral index and diabetes risk in the US population- a case study.Journal of diabetes and metabolic disorders · 2023Article
- Adult Body Height Is Associated with the Risk of Type 2 but Not Type 1 Diabetes Mellitus: A Retrospective Cohort Study of 783,029 Individuals in Germany.Journal of clinical medicine · 2023Article
- Upper arm length and knee height are associated with diabetes in the middle-aged and elderly: evidence from the China Health and Retirement Longitudinal Study.Public health nutrition · 2023Article
- Implications of leg length for metabolic health and fitness.Evolution, medicine, and public health · 2022Article
- The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study.International journal of environmental research and public health · 2021Article
- Body Composition Methods in Adults with Type 2 Diabetes or at Risk for T2D: a Clinical Review.Current diabetes reports · 2021Review
- Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors.Diabetologia · 2019Article
- Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study.Scientific reports · 2019Article
- Early-life nutritional status and metabolic syndrome: gender-specific associations from a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Public health nutrition · 2018Article
- Explaining ethnic disparities in lung function among young adults: A pilot investigation.PloS one · 2017Article
- Leg length and type 2 diabetes: what's the link?Current opinion in clinical nutrition and metabolic care · 2015Review
- Shorter adult height is associated with poorer cognitive performance in elderly men with type II diabetes.Journal of Alzheimer's disease : JAD · 2015Article
- Association between leg length-to-height ratio and metabolic syndrome in Chinese children aged 3 to 6 years.Preventive medicine reports · 2014Article
- Final height and cardiometabolic outcomes in young adults with very low birth weight (<1500 g).PloS one · 2014Article
- Dual X-Ray absorptiometry leg length in youth.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryArticle
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Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveShort leg length, a marker of early childhood deprivation, has been used in studies of the association of early life conditions with adult chronic disease risk. The objective of this study was to determine the cross-sectional associations of leg length with measures of insulin sensitivity and β-cell function. RESEARCH DESIGN AND
methodsSubjects (n = 462) at risk for type 2 diabetes were recruited into the PROspective Metabolism and ISlet cell Evaluation (PROMISE) longitudinal cohort. Leg length was calculated from sitting and standing height at the 3-year clinical examination. Glucose tolerance status was determined using an oral glucose tolerance test. Insulin sensitivity was assessed using homeostasis model assessment of insulin resistance (HOMA-IR) and the Matsuda insulin sensitivity index (ISI), while the insulinogenic index over HOMA-IR (IGI/IR) and the insulin secretion sensitivity index 2 (ISSI-2) determined β-cell function. Multiple linear regression analysis was conducted, adjusting for covariates including age, sex, ethnicity, family history of diabetes, waist, and weight.
resultsLeg length and leg-to-height ratio were significantly associated with HOMA-IR (β = -0.037, β = -10.49, respectively; P < 0.0001), ISI (β = 0.035, β = 8.83, respectively; P < 0.0001), IGI/IR (β = 0.021, P < 0.05; β = 7.60, P < 0.01, respectively), and ISSI-2 (β = 0.01, P < 0.03; β = 3.34, P < 0.01, respectively) after adjustment for covariates. The association of shorter leg length with lower insulin sensitivity was most evident for those with high waist circumferences.
conclusionsShorter legs were independently associated with lower insulin sensitivity and β-cell function, suggesting that early childhood deprivation may increase the risk of developing diabetes.
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