ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Superficially projecting principal neurons in layer V of medial entorhinal cortex in the rat receive excitatory retrosplenial input.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 63 citations in OpenAlex.
- The entorhinal spatial map integrates visual identity information of landmarks.Nature communications · 2026Article
- The medial entorhinal cortex encodes multisensory spatial information.Cell reports · 2024Article
- FOS mapping reveals two complementary circuits for spatial navigation in mouse.Scientific reports · 2024Article
- Retrosplenial inputs drive visual representations in the medial entorhinal cortex.Cell reports · 2024Article
- Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.Brain structure & function · 2024Article
- Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex.bioRxiv : the preprint server for biology · 2023Article
- Exploiting semantic information in a spiking neural SLAM system.Frontiers in neuroscience · 2023Article
- Retrosplenial and subicular inputs converge on superficially projecting layer V neurons of medial entorhinal cortex.Brain structure & function · 2022Article
- Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus.eLife · 2022Article
- Retrosplenial cortex in spatial memory: focus on immediate early genes mapping.Molecular brain · 2021Review
- Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory.Neurobiology of learning and memory · 2021Article
- Strategy-Specific Patterns ofBrain sciences · 2020Article
- Role of retrosplenial cortex in processing stress-related context memories.Behavioral neuroscience · 2018Review
- Article
- Hippocampus-dependent emergence of spatial sequence coding in retrosplenial cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Neural mechanisms of navigation involving interactions of cortical and subcortical structures.Journal of neurophysiology · 2018Review
- Retrosplenial cortex and its role in spatial cognition.Brain and neuroscience advances · 2018Review
- Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?Trends in neurosciences · 2017Review
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Principal cells in layer V of the medial entorhinal cortex (MEC) have a nodal position in the cortical-hippocampal network. They are the main recipients of hippocampal output and receive inputs from several cortical areas, including a prominent one from the retrosplenial cortex (RSC), likely targeting basal dendrites of layer V neurons. The latter project to extrahippocampal structures but also relay information to the superficial layers of MEC, closing the hippocampal-entorhinal loop. In the rat, we electrophysiologically and morphologically characterized RSC input into MEC and conclude that RSC provides an excitatory input to layer V pyramidal cells. Ultrastructural analyses of anterogradely labeled RSC projections showed that RSC axons in layer V of MEC form predominantly asymmetrical, likely excitatory, synapses on dendritic spines (90%) or shafts (8%), with 2% symmetrical, likely inhibitory, synapses on shafts and spines. The overall excitatory nature of the RSC input was confirmed by an optogenetic approach. Patterned laser stimulation of channelrhodopsin-expressing presynaptic RSC axons evoked exclusively EPSPs in recorded postsynaptic layer V cells. All responding layer V pyramidal cells had an axon extending toward the white matter. Half of these neurons also sent an axon to superficial layers. Confocal imaging of RSC synapses onto MEC layer V neurons shown to project superficially by way of retrogradely labeling from superficial layers confirmed that proximal dendrites of superficially projecting cells are among the targets of inputs from RSC. The excitatory RSC input thus interacts with both entorhinal-cortical and entorhinal-hippocampal circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.