ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 66 citations in OpenAlex.
- Neuronal correlates of spatial memory updating: c-Fos and GAD67 expression in the object-place recognition task.Scientific reports · 2026Article
- The pERKs of temporal order memory in mice.Frontiers in molecular neuroscience · 2026Article
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Retrosplenial cortex 5-HT2A receptors critically contribute to recognition memory processing.Frontiers in cellular neuroscience · 2025Article
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
- Dual role of α7 nicotinic acetylcholine receptors in the retrosplenial cortex for aversive memory acquisition and retrieval.Frontiers in behavioral neuroscience · 2024Article
- Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice.International journal of molecular sciences · 2022Article
- Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modulating role of serotonergic signaling in sleep and memory.Pharmacological reports : PR · 2022Review
- Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe.Psychopharmacology · 2021Article
- Article
- Serotonergic Innervations of the Orbitofrontal and Medial-prefrontal Cortices are Differentially Involved in Visual Discrimination and Reversal Learning in Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Serotonin in the rat prefrontal cortex controls the micturition reflex through 5-hydroxytryptamine 2A and 5-hydroxytryptamine 7 receptors.International journal of urology : official journal of the Japanese Urological Association · 2020Article
- The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties.Neuroscience and biobehavioral reviews · 2020Review
- Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model.Scientific reports · 2020Article
- Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula.International journal of molecular sciences · 2020Article
- A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities.IBRO reports · 2019Article
- Alterations in serotonin transporter and body image-related cognition in anorexia nervosa.NeuroImage. Clinical · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- 5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex.eLife · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Often, retrieval cues are not uniquely related to one specific memory, which could lead to memory interference. Controlling interference is particularly important during episodic memory retrieval or when remembering specific events in a spatiotemporal context. Despite a clear involvement of prefrontal cortex (PFC) in episodic memory in human studies, information regarding the mechanisms and neurotransmitter systems in PFC involved in memory is scarce. Although the serotoninergic system has been linked to PFC functionality and modulation, its role in memory processing is poorly understood. We hypothesized that the serotoninergic system in PFC, in particular the 5-HT2A receptor (5-HT2AR) could have a role in the control of memory retrieval. In this work we used different versions of the object recognition task in rats to study the role of the serotoninergic modulation in the medial PFC (mPFC) in memory retrieval. We found that blockade of 5-HT2AR in mPFC affects retrieval of an object in context memory in a spontaneous novelty preference task, while sparing single-item recognition memory. We also determined that 5-HT2ARs in mPFC are required for hippocampal-mPFC interaction during retrieval of this type of memory, suggesting that the mPFC controls the expression of memory traces stored in the hippocampus biasing retrieval to the most relevant one.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.