ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons.Brain research · 2025Article
- Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy.PLoS computational biology · 2025Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Long-Lasting, Pathway-Specific Impairment of a Novel Form of Spike-Timing-Dependent Long-Term Depression by Neuropathic Pain in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mild stress accumulation limits GABAergic synaptic plasticity in the lateral habenula.The European journal of neuroscience · 2022Article
- Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain.Scientific reports · 2021Article
- Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses.eLife · 2021Article
- Neural Burst Firing and Its Roles in Mental and Neurological Disorders.Frontiers in cellular neuroscience · 2021Article
- Efficient Low-Pass Dendro-Somatic Coupling in the Apical Dendrite of Layer 5 Pyramidal Neurons in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output.Nature communications · 2020Article
- Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.Brain : a journal of neurology · 2020Review
- Repeated cathodal transspinal pulse and direct current stimulation modulate cortical and corticospinal excitability differently in healthy humans.Experimental brain research · 2019Article
- Dendritic processing of spontaneous neuronal sequences for single-trial learning.Scientific reports · 2018Article
- Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.Nature reviews. Neuroscience · 2018Review
- Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells.Scientific reports · 2017Article
- The brain-penetrant 5-HTNeurobiology of disease · 2017Article
- Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs.Scientific reports · 2017Article
- Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- T-type calcium channels in synaptic plasticity.Channels (Austin, Tex.) · 2017Review
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamus integrates and transmits sensory information to the neocortex. The activity of thalamocortical relay (TC) cells is modulated by specific inhibitory circuits. Although this inhibition plays a crucial role in regulating thalamic activity, little is known about long-term changes in synaptic strength at these inhibitory synapses. Therefore, we studied long-term plasticity of inhibitory inputs to TC cells in the posterior medial nucleus of the thalamus by combining patch-clamp recordings with two-photon fluorescence microscopy in rat brain slices. We found that specific activity patterns in the postsynaptic TC cell induced inhibitory long-term potentiation (iLTP). This iLTP was non-Hebbian because it did not depend on the timing between presynaptic and postsynaptic activity, but it could be induced by postsynaptic burst activity alone. iLTP required postsynaptic dendritic Ca(2+) influx evoked by low-threshold Ca(2+) spikes. In contrast, tonic postsynaptic spiking from a depolarized membrane potential (-50 mV), which suppressed these low-threshold Ca(2+) spikes, induced no plasticity. The postsynaptic dendritic Ca(2+) increase triggered the synthesis of nitric oxide that retrogradely activated presynaptic guanylyl cyclase, resulting in the presynaptic expression of iLTP. The dependence of iLTP on the membrane potential and therefore on the postsynaptic discharge mode suggests that this form of iLTP might occur during sleep, when TC cells discharge in bursts. Therefore, iLTP might be involved in sleep state-dependent modulation of thalamic information processing and thalamic oscillations.
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