ArticleAmerican journal of physiology. Renal physiology2013
A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Plasma oxalate and eGFR are correlated in primary hyperoxaluria patients with maintained kidney function-data from three placebo-controlled studies.Pediatric nephrology (Berlin, Germany) · 2021Trial
- A randomised Phase II/III study to evaluate the efficacy and safety of orally administered Oxalobacter formigenes to treat primary hyperoxaluria.Urolithiasis · 2018Trial
- A randomised Phase I/II trial to evaluate the efficacy and safety of orally administered Oxalobacter formigenes to treat primary hyperoxaluria.Pediatric nephrology (Berlin, Germany) · 2017Trial
- Urine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Oxalate homeostasis.Nature reviews. Nephrology · 2023Review
- Increased abundance of bacteria of the family Muribaculaceae achieved by fecal microbiome transplantation correlates with the inhibition of kidney calcium oxalate stone deposition in experimental rats.Frontiers in cellular and infection microbiology · 2023Article
- End Points for Clinical Trials in Hyperoxaluria: Case Study of Patient-Focused Drug Development in a Rare Disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Primary hyperoxaluria: the adult nephrologist's point of view.Clinical kidney journal · 2022Review
- Primary hyperoxaluria type 1: pathophysiology and genetics.Clinical kidney journal · 2022Review
- Detection and localization of calcium oxalate in kidney using synchrotron deep ultraviolet fluorescence microscopy.Journal of synchrotron radiation · 2022Article
- Posttransplant recurrence of calcium oxalate crystals in patients with primary hyperoxaluria: Incidence, risk factors, and effect on renal allograft function.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Plasma Oxalate as a Predictor of Kidney Function Decline in a Primary Hyperoxaluria Cohort.International journal of molecular sciences · 2020Article
- Urinary monocyte chemoattractant protein 1 associated with calcium oxalate crystallization in patients with primary hyperoxaluria.BMC nephrology · 2020Article
- Article
- Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease.The Journal of clinical investigation · 2019Article
- Dietary oxalate and kidney stone formation.American journal of physiology. Renal physiology · 2019Review
- Recent advances in the identification and management of inherited hyperoxalurias.Urolithiasis · 2019Review
- SGLT2 Inhibitors and Mechanisms of Hypertension.Current cardiology reports · 2018 · on this mapReview
- Plasma oxalate in relation to eGFR in patients with primary hyperoxaluria, enteric hyperoxaluria and urinary stone disease.Clinical biochemistry · 2017Article
- Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.Journal of the American Society of Nephrology : JASN · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
The sequence of events by which primary hyperoxaluria type 1 (PH1) causes renal failure is unclear. We hypothesize that proximal tubule (PT) is vulnerable because oxalate secretion raises calcium oxalate (CaOx) supersaturation (SS) there, leading to crystal formation and cellular injury. We studied cortical and papillary biopsies from two PH1 patients with preserved renal function, and seven native kidneys removed from four patients at the time of transplant, after short-term (2) or longer term (2) dialysis. In these patients, and another five PH1 patients without renal failure, we calculated oxalate secretion, and estimated PT CaOx SS. Plasma oxalate was elevated in all PH1 patients and inverse to creatinine clearance. Renal secretion of oxalate was present in all PH1 but rare in controls. PT CaOx SS was >1 in all nonpyridoxine-responsive PH1 before transplant and most marked in patients who developed end stage renal disease (ESRD). PT from PH1 with preserved renal function had birefringent crystals, confirming the presence of CaOx SS, but had no evidence of cortical inflammation or scarring by histopathology or hyaluronan staining. PH1 with short ESRD showed CaOx deposition and hyaluronan staining particularly at the corticomedullary junction in distal PT while cortical collecting ducts were spared. Longer ESRD showed widespread cortical CaOx, and in both groups papillary tissue had marked intratubular CaOx deposits and fibrosis. CaOx SS in PT causes CaOx crystal formation, and CaOx deposition in distal PT appears to be associated with ESRD. Minimizing PT CaOx SS may be important for preserving renal function in PH1.
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