ArticleJournal of neurophysiology2013
Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Mixed Representations of Sound and Action in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning.Frontiers in molecular neuroscience · 2024Article
- The Basal Ganglia and Mesencephalic Locomotor Region Connectivity Matrix.Current neuropharmacology · 2024Review
- Mixed representations of sound and action in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
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- Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism.Nature communications · 2022Article
- Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits.Journal of neurophysiology · 2021Article
- Dichotomy between motor and cognitive functions of midbrain cholinergic neurons.Neurobiology of disease · 2019Review
- Spatial representations in the superior colliculus are modulated by competition among targets.Neuroscience · 2019Article
- The Role of Cholinergic Midbrain Neurons in Startle and Prepulse Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.eLife · 2017Article
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- Article
- Structural and functional considerations of the cholinergic brainstem.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- The pedunculopontine tegmental nucleus-A functional hypothesis from the comparative literature.Movement disorders : official journal of the Movement Disorder Society · 2016Review
- Pedunculopontine tegmental nucleus lesions impair probabilistic reversal learning by reducing sensitivity to positive reward feedback.Neurobiology of learning and memory · 2016Article
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- Reward and Behavioral Factors Contributing to the Tonic Activity of Monkey Pedunculopontine Tegmental Nucleus Neurons during Saccade Tasks.Frontiers in systems neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies across several mammalian species have revealed a distributed network of cortical and subcortical brain regions responsible for sensorimotor decision making. Many of these regions have been shown to be interconnected with the pedunculopontine tegmental nucleus (PPTg), a brain stem structure characterized by neuronal heterogeneity and thought to be involved in several cognitive and behavioral functions. However, whether this structure plays a general functional role in sensorimotor decision making is unclear. We hypothesized that, in the context of a sensorimotor task, activity in the PPTg would reflect task-related variables in a similar manner as do the cortical and subcortical regions with which it is anatomically associated. To examine this hypothesis, we recorded PPTg activity in mice performing an odor-cued spatial choice task requiring a stereotyped leftward or rightward orienting movement to obtain a reward. We studied single-neuron activity during epochs of the task related to movement preparation, execution, and outcome (i.e., whether or not the movement was rewarded). We found that a substantial proportion of neurons in the PPTg exhibited direction-selective activity during one or more of these epochs. In addition, an overlapping population of neurons reflected movement direction and reward outcome. These results suggest that the PPTg should be considered within the network of brain areas responsible for sensorimotor decision making and lay the foundation for future experiments to examine how the PPTg interacts with other regions to control sensory-guided motor output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.