ArticleJournal of neurophysiology2013
Multisensory integration in early vestibular processing in mice: the encoding of passive vs. active motion.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Cerebellar Purkinje cells in male macaques combine sensory and motor information to predict the sensory consequences of active self-motion.Nature communications · 2024Article
- Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A dynamic sequence of visual processing initiated by gaze shifts.Nature neuroscience · 2023Article
- Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.Annual review of neuroscience · 2023Review
- Coherent mapping of position and head direction across auditory and visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
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- Role of locomotor efference copy in vertebrate gaze stabilization.Frontiers in neural circuits · 2022Review
- Mapping vestibular and visual contributions to angular head velocity tuning in the cortex.Cell reports · 2021Article
- Proprioception and the predictive sensing of active self-motion.Current opinion in physiology · 2021Article
- Predictive Sensing: The Role of Motor Signals in Sensory Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Our sense of direction: progress, controversies and challenges.Nature neuroscience · 2017Review
- Moving or being moved: that makes a difference.Journal of neurology · 2017Review
- Persistent perceptual delay for active head movement onset relative to sound onset with and without vision.Experimental brain research · 2017Article
- Magnetic eye tracking in mice.eLife · 2017Article
- The integration of neural information by a passive kinetic stimulus and galvanic vestibular stimulation in the lateral vestibular nucleus.Medical & biological engineering & computing · 2017Article
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Corrections and comments
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2 authors.
Funding
Abstract
The mouse has become an important model system for studying the cellular basis of learning and coding of heading by the vestibular system. Here we recorded from single neurons in the vestibular nuclei to understand how vestibular pathways encode self-motion under natural conditions, during which proprioceptive and motor-related signals as well as vestibular inputs provide feedback about an animal's movement through the world. We recorded neuronal responses in alert behaving mice focusing on a group of neurons, termed vestibular-only cells, that are known to control posture and project to higher-order centers. We found that the majority (70%, n = 21/30) of neurons were bimodal, in that they responded robustly to passive stimulation of proprioceptors as well as passive stimulation of the vestibular system. Additionally, the linear summation of a given neuron's vestibular and neck sensitivities predicted well its responses when both stimuli were applied simultaneously. In contrast, neuronal responses were suppressed when the same motion was actively generated, with the one striking exception that the activity of bimodal neurons similarly and robustly encoded head on body position in all conditions. Our results show that proprioceptive and motor-related signals are combined with vestibular information at the first central stage of vestibular processing in mice. We suggest that these results have important implications for understanding the multisensory integration underlying accurate postural control and the neural representation of directional heading in the head direction cell network of mice.
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Registered trials
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