ArticleProceedings. Biological sciences2013
Multiple pathways mediate the sex-peptide-regulated switch in female Drosophila reproductive behaviours.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 94 citations in OpenAlex.
- Article
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- Venerose: a nuptial gift with implications.Journal of neurogenetics · 2025Article
- Structure-optimized sgRNA selection with PlatinumCRISPr for efficient Cas9 generation of knockouts.Genome research · 2024Article
- Rapid evolution of promoters from germline-specifically expressed genes including transposon silencing factors.BMC genomics · 2024Article
- Decoupled evolution of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoupled evolution of thebioRxiv : the preprint server for biology · 2023Article
- Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract.BMC genomics · 2023Article
- Indel driven rapid evolution of core nuclear pore protein gene promoters.Scientific reports · 2023Article
- Time series transcriptome analysis implicates the circadian clock in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- CRISPR/Cas9-induced Mutation of Sex Peptide Receptor Gene Bdspr Affects Ovary, Egg Laying, and Female Fecundity in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).Journal of insect science (Online) · 2023Article
- Mating disrupts morning anticipation in Drosophila melanogaster females.PLoS genetics · 2022Article
- On the Role of Seminal Fluid Protein and Nucleic Acid Content in Paternal Epigenetic Inheritance.International journal of molecular sciences · 2022Review
- Serotonin Signaling Modulates Sexual Receptivity of Virgin Female Drosophila.Neuroscience bulletin · 2022Article
- CMTr mediated 2'-RNA (New York, N.Y.) · 2022Article
- The evolution of sex peptide: sexual conflict, cooperation, and coevolution.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Review
- Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila.BMC biology · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male-derived sex-peptide (SP) induces profound changes in the behaviour of Drosophila females, resulting in decreased receptivity to further mating and increased egg laying. SP can mediate the switch in female reproductive behaviours via a G protein-coupled receptor, SPR, in neurons expressing fruitless, doublesex and pickpocket. Whether SPR is the sole receptor and whether SP induces the postmating switch in a single pathway has not, to our knowledge been tested. Here we report that the SP response can be induced in the absence of SPR when SP is ectopically expressed in neurons or when SP, transferred by mating, can access neurons through a leaky blood brain barrier. Membrane-tethered SP can induce oviposition via doublesex, but not fruitless and pickpocket neurons in SPR mutant females. Although pickpocket and doublesex neurons rely on G(o) signalling to reduce receptivity and induce oviposition, G(o) signalling in fruitless neurons is required only to induce oviposition, but not to reduce receptivity. Our results show that SP's action in reducing receptivity and inducing oviposition can be separated in fruitless and doublesex neurons. Hence, the SP-induced postmating switch incorporates shared, but also distinct circuitry of fruitless, doublesex and pickpocket neurons and additional receptors.
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