ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 68 citations in OpenAlex.
- CD1a and Lipids as Mediators of T Cell Activation in the Skin.The Journal of investigative dermatology · 2025Review
- Diet-induced dyslipidemia enhances IFN-γ production in mycolic acid-specific T cells and affects mycobacterial control.Mucosal immunology · 2025Article
- Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells.Immunology and cell biology · 2024Review
- History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.PLoS genetics · 2024Article
- Article
- CD1a and bound lipids drive T-cell responses in human skin disease.European journal of immunology · 2023Review
- Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.Nature immunology · 2023Article
- UcTCRdb: An unconventional T cell receptor sequence database with online analysis functions.Frontiers in immunology · 2023Article
- CD1a promotes systemic manifestations of skin inflammation.Nature communications · 2022Article
- Unconventional T cells and kidney disease.Nature reviews. Nephrology · 2021Review
- Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System.Molecules and cells · 2021Review
- The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity.Immunological reviews · 2021Review
- T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- CD1a function in human skin disease.Molecular immunology · 2021Review
- Human skin is colonized by T cells that recognize CD1a independently of lipid.The Journal of clinical investigation · 2021Article
- Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?Frontiers in immunology · 2021Article
- Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.Critical reviews in immunology · 2021Article
- Review
- T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion.International journal of molecular sciences · 2020Review
- Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 6 countries.
Funding
Abstract
Human CD1a mediates foreign Ag recognition by a T cell clone, but the nature of possible TCR interactions with CD1a/lipid are unknown. After incubating CD1a with a mycobacterial lipopeptide Ag, dideoxymycobactin (DDM), we identified and measured binding to a recombinant TCR (TRAV3/ TRBV3-1, KD of ≈100 μM). Detection of ternary CD1a/lipid/TCR interactions enabled development of CD1a tetramers and CD1a multimers with carbohydrate backbones (dextramers), which specifically stained T cells using a mechanism that was dependent on the precise stereochemistry of the peptide backbone and was blocked with a soluble TCR. Furthermore, sorting of human T cells from unrelated tuberculosis patients for bright DDM-dextramer staining allowed recovery of T cells that were activated by CD1a and DDM. These studies demonstrate that the mechanism of T cell activation by lipopeptides occurs via ternary interactions of CD1a/Ag/TCR. Furthermore, these studies demonstrate the existence of lipopeptide-specific T cells in humans ex vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.